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Intraocular penetration of intravenous micafungin in inflamed human eyes.
- Source :
-
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2013 Aug; Vol. 57 (8), pp. 4027-30. Date of Electronic Publication: 2013 May 20. - Publication Year :
- 2013
-
Abstract
- Eight eyes of 7 patients with fungal disease received intravenous injections of 150 to 300 mg micafungin, and samples of blood, cornea, retina-choroid, aqueous humor, and vitreous humor were collected. The micafungin levels in all collected samples exceeded the MICs; however, the levels in the vitreous and aqueous humors were lower. Our findings suggest that intravenous micafungin should be given in combination with intravitreal antifungal agents after vitrectomy in severe cases of intraocular fungal diseases.
- Subjects :
- Aged
Aged, 80 and over
Antifungal Agents pharmacokinetics
Aqueous Humor metabolism
Aspergillus drug effects
Aspergillus isolation & purification
Candida drug effects
Candida isolation & purification
Cornea drug effects
Echinocandins pharmacokinetics
Endophthalmitis microbiology
Female
Humans
Injections, Intraocular methods
Lipopeptides pharmacokinetics
Male
Micafungin
Vitrectomy methods
Vitreous Body metabolism
Antifungal Agents administration & dosage
Cornea microbiology
Echinocandins administration & dosage
Endophthalmitis drug therapy
Lipopeptides administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1098-6596
- Volume :
- 57
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Antimicrobial agents and chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 23689706
- Full Text :
- https://doi.org/10.1128/AAC.02300-12