Back to Search
Start Over
Monte Carlo study of the dose enhancement effect of gold nanoparticles during X-ray therapies and evaluation of the anti-angiogenic effect on tumour capillary vessels.
- Source :
-
Journal of X-ray science and technology [J Xray Sci Technol] 2013; Vol. 21 (2), pp. 237-47. - Publication Year :
- 2013
-
Abstract
- Gold nanoparticles (GNPs) are a promising radiosensitizer agent in radiotherapy. Through a simulation performed with the Geant4 Monte Carlo code, we evaluated the dose enhancement effect of GNPs during therapies with an x-ray tube operating at 150 kV (E = 55 keV and E(max) = 150 keV) and we studied the impact of GNP diffusion out of the tumour vessels, in terms of antiangiogenic and cytotoxic effects. Firstly, a single x-ray beam was assumed to irradiate a parallelepiped volume of soft tissue, in which a GNP-doped "target" volume was placed at different depths. Average dose enhancement factors (DEF) in presence of GNPs were obtained as a function of the target depth and GNP concentration, uniformly distributed; values ranging between 1.6 for 10 mg Au/g at 0 cm and 7.2 for 200 mg Au/g at 5 cm were determined. Furtherly, a second geometry was adopted, in which a blood capillary vessel (10 μm thick and 10 μm of inner radius) was placed at the centre of a cubic volume of soft tissue; doses and DEFs to the capillary endothelium as well as to the surrounding viable tumour were evaluated, for different models of GNP diffusion. Our results indicate that the radial DEF profiles around the vessel are in close relationship with the radial profiles of GNP concentration assumed, except for at sharp gradients of concentration. DEFs at the endothelium ranged from 1.6 to 6.5, for GNP concentrations in the blood of 10 and 200 mg/ml, respectively. These data can be helpful for the development of new and more specific GNP-based radiosensitizers of potential interest in radiotherapy, exploiting the combined benefit of anti-angiogenic and cytotoxic dose enhancement effects.
- Subjects :
- Angiogenesis Inhibitors chemistry
Animals
Computer Simulation
Diffusion
Endothelial Cells drug effects
Endothelial Cells radiation effects
Gold chemistry
Metal Nanoparticles chemistry
Mice
Monte Carlo Method
Neoplasms, Experimental drug therapy
Neoplasms, Experimental radiotherapy
Phantoms, Imaging
Radiation-Sensitizing Agents administration & dosage
Radiation-Sensitizing Agents chemistry
Radiotherapy Dosage
Angiogenesis Inhibitors administration & dosage
Gold pharmacology
Metal Nanoparticles administration & dosage
Models, Biological
Neoplasms, Experimental blood supply
Neoplasms, Experimental therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1095-9114
- Volume :
- 21
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of X-ray science and technology
- Publication Type :
- Academic Journal
- Accession number :
- 23694913
- Full Text :
- https://doi.org/10.3233/XST-130374