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Gene expression profiling reveals distinct features of various porcine adipose tissues.
- Source :
-
Lipids in health and disease [Lipids Health Dis] 2013 May 24; Vol. 12, pp. 75. Date of Electronic Publication: 2013 May 24. - Publication Year :
- 2013
-
Abstract
- Background: The excessive accumulation of body fat is a major risk factor to develop a variety of metabolic diseases. To investigate the systematic association between the differences in gene expression profiling and adipose deposition, we used pig as a model, and measured the gene expression profiling of six variant adipose tissues in male and females from three pig breeds which display distinct fat level.<br />Results: We identified various differential expressed genes among breeds, tissues and between sexes, and further used a clustering method to identify sets of functionally co-expression genes linked to different obesity-related phenotypes. Our results reveal that the subcutaneous adipose tissues mainly modulate metabolic indicators, nonetheless, the visceral adipose tissues as well as the intermuscular adipose tissue were mainly associated with the impaired inflammatory and immune response.<br />Conclusions: The present study provided the evidence of gene expression profiling that the subcutaneous adipose tissues are mainly affected the metabolism process, whereas the visceral and intermuscular adipose tissues should been term as the metabolic risk factors of obesity.
- Subjects :
- Adipose Tissue metabolism
Animals
Disease Models, Animal
Female
Humans
Intra-Abdominal Fat pathology
Male
Metabolic Diseases pathology
Obesity genetics
Obesity metabolism
Oligonucleotide Array Sequence Analysis
Risk Factors
Subcutaneous Fat pathology
Swine
Gene Expression Profiling
Intra-Abdominal Fat metabolism
Metabolic Diseases genetics
Subcutaneous Fat metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1476-511X
- Volume :
- 12
- Database :
- MEDLINE
- Journal :
- Lipids in health and disease
- Publication Type :
- Academic Journal
- Accession number :
- 23705929
- Full Text :
- https://doi.org/10.1186/1476-511X-12-75