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Neuroligin-1 links neuronal activity to sleep-wake regulation.
Neuroligin-1 links neuronal activity to sleep-wake regulation.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2013 Jun 11; Vol. 110 (24), pp. 9974-9. Date of Electronic Publication: 2013 May 28. - Publication Year :
- 2013
-
Abstract
- Maintaining wakefulness is associated with a progressive increase in the need for sleep. This phenomenon has been linked to changes in synaptic function. The synaptic adhesion molecule Neuroligin-1 (NLG1) controls the activity and synaptic localization of N-methyl-d-aspartate receptors, which activity is impaired by prolonged wakefulness. We here highlight that this pathway may underlie both the adverse effects of sleep loss on cognition and the subsequent changes in cortical synchrony. We found that the expression of specific Nlg1 transcript variants is changed by sleep deprivation in three mouse strains. These observations were associated with strain-specific changes in synaptic NLG1 protein content. Importantly, we showed that Nlg1 knockout mice are not able to sustain wakefulness and spend more time in nonrapid eye movement sleep than wild-type mice. These changes occurred with modifications in waking quality as exemplified by low theta/alpha activity during wakefulness and poor preference for social novelty, as well as altered delta synchrony during sleep. Finally, we identified a transcriptional pathway that could underlie the sleep/wake-dependent changes in Nlg1 expression and that involves clock transcription factors. We thus suggest that NLG1 is an element that contributes to the coupling of neuronal activity to sleep/wake regulation.
- Subjects :
- Animals
Blotting, Western
Cell Adhesion Molecules, Neuronal genetics
Cell Adhesion Molecules, Neuronal metabolism
Electroencephalography
Electromyography
Gene Expression
Male
Mice
Mice, 129 Strain
Mice, Inbred AKR
Mice, Inbred C57BL
Mice, Inbred DBA
Mice, Knockout
Neurons metabolism
Reverse Transcriptase Polymerase Chain Reaction
Sleep genetics
Sleep Deprivation genetics
Sleep Deprivation physiopathology
Species Specificity
Time Factors
Wakefulness genetics
Cell Adhesion Molecules, Neuronal physiology
Neurons physiology
Sleep physiology
Wakefulness physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1091-6490
- Volume :
- 110
- Issue :
- 24
- Database :
- MEDLINE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 23716671
- Full Text :
- https://doi.org/10.1073/pnas.1221381110