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Neural coding during active somatosensation revealed using illusory touch.
- Source :
-
Nature neuroscience [Nat Neurosci] 2013 Jul; Vol. 16 (7), pp. 958-65. Date of Electronic Publication: 2013 Jun 02. - Publication Year :
- 2013
-
Abstract
- Active sensation requires the convergence of external stimuli with representations of body movements. We used mouse behavior, electrophysiology and optogenetics to dissect the temporal interactions among whisker movement, neural activity and sensation of touch. We photostimulated layer 4 activity in single barrels in a closed loop with whisking. Mimicking touch-related neural activity caused illusory perception of an object at a particular location, but scrambling the timing of the spikes over one whisking cycle (tens of milliseconds) did not abolish the illusion, indicating that knowledge of instantaneous whisker position is unnecessary for discriminating object locations. The illusions were induced only during bouts of directed whisking, when mice expected touch, and in the relevant barrel. Reducing activity biased behavior, consistent with a spike count code for object detection at a particular location. Our results show that mice integrate coding of touch with movement over timescales of a whisking bout to produce perception of active touch.
- Subjects :
- Action Potentials genetics
Afferent Pathways physiology
Animals
Channelrhodopsins
DNA-Binding Proteins genetics
Epithelial Sodium Channels genetics
Eye Proteins genetics
GABAergic Neurons physiology
Homeodomain Proteins genetics
Illusions genetics
Mice
Mice, Inbred C57BL
Mice, Transgenic
Nerve Tissue Proteins genetics
Optogenetics
Physical Stimulation
Reaction Time physiology
Transcription Factors genetics
Vesicular Inhibitory Amino Acid Transport Proteins genetics
Video Recording
Homeobox Protein SIX3
Action Potentials physiology
Discrimination, Psychological physiology
Illusions physiology
Neurons physiology
Somatosensory Cortex cytology
Vibrissae innervation
Subjects
Details
- Language :
- English
- ISSN :
- 1546-1726
- Volume :
- 16
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Nature neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 23727820
- Full Text :
- https://doi.org/10.1038/nn.3419