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Evidence for mendelian inheritance in the pathogenesis of lung cancer.

Authors :
Sellers TA
Bailey-Wilson JE
Elston RC
Wilson AF
Elston GZ
Ooi WL
Rothschild H
Source :
Journal of the National Cancer Institute [J Natl Cancer Inst] 1990 Aug 01; Vol. 82 (15), pp. 1272-9.
Publication Year :
1990

Abstract

Segregation analyses that allowed for variable age of onset of lung cancer and smoking history were performed on 337 families, each ascertained through a lung cancer proband. Results indicated compatibility of the data with mendelian codominant inheritance of a rare major autosomal gene that produces earlier age of onset of the cancer. Segregation at this putative locus could account for 69% and 47% of the cumulative incidence of lung cancer in individuals up to ages 50 and 60, respectively. The gene was involved in only 22% of all lung cancers in persons up to age 70, a reflection of an increasing proportion of noncarriers succumbing to the effects of long-term exposure to tobacco.

Details

Language :
English
ISSN :
0027-8874
Volume :
82
Issue :
15
Database :
MEDLINE
Journal :
Journal of the National Cancer Institute
Publication Type :
Academic Journal
Accession number :
2374177
Full Text :
https://doi.org/10.1093/jnci/82.15.1272