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Evidence for mendelian inheritance in the pathogenesis of lung cancer.
- Source :
-
Journal of the National Cancer Institute [J Natl Cancer Inst] 1990 Aug 01; Vol. 82 (15), pp. 1272-9. - Publication Year :
- 1990
-
Abstract
- Segregation analyses that allowed for variable age of onset of lung cancer and smoking history were performed on 337 families, each ascertained through a lung cancer proband. Results indicated compatibility of the data with mendelian codominant inheritance of a rare major autosomal gene that produces earlier age of onset of the cancer. Segregation at this putative locus could account for 69% and 47% of the cumulative incidence of lung cancer in individuals up to ages 50 and 60, respectively. The gene was involved in only 22% of all lung cancers in persons up to age 70, a reflection of an increasing proportion of noncarriers succumbing to the effects of long-term exposure to tobacco.
Details
- Language :
- English
- ISSN :
- 0027-8874
- Volume :
- 82
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Journal of the National Cancer Institute
- Publication Type :
- Academic Journal
- Accession number :
- 2374177
- Full Text :
- https://doi.org/10.1093/jnci/82.15.1272