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Clinical characteristics and outcome in multibacillary (MB) leprosy patients treated with 12 months WHO MDT-MBR: a retrospective analysis of 730 patients from a leprosy clinic at a tertiary care hospital of Northern India.
- Source :
-
Leprosy review [Lepr Rev] 2013 Mar; Vol. 84 (1), pp. 65-75. - Publication Year :
- 2013
-
Abstract
- Background: Shortened (12 months) multidrug multibacillary regimen (MDT MBR) was implemented in India in 1998, however there is yet a paucity of crucial data on its long-term outcome.<br />Objective: To assess the efficacy of 12 months MDT MBR in multibacillary (MB) patients at our centre.<br />Design: This was a retrospective study undertaken analysing the clinic records of 1210 patients registered at the leprosy clinic of our institute from 1999 to 2010.<br />Results: 730 MB patients were treated with 12 months MDT MBR over this period. High bacillary index (BI) > or = 3 + was observed in 313 patients at the time of registration. Four hundred and one (54.9%) patients experienced lepra reactions. Recurrent ENL was observed in only 14 patients which manifested even after 5 years of stopping treatment. Clinico-histological correlation was noted in 361 (49.5%) patients. During follow up period ranging from 9 months to 10 years, nearly all patients had clearance of skin lesions including histopathological/bacteriological improvement. Only 13 (1.7%) patients relapsed.<br />Conclusions: All patients responded well with 12 months MDT MBR without significant side effects. The overall relapse rate was only 1.7%. Thus, the recommendation for 12 months MDT MBR for all MB patients is robust and operationally practical, a decision which seems logical.
- Subjects :
- Adolescent
Adult
Drug Therapy, Combination
Female
Follow-Up Studies
Humans
India
Male
Middle Aged
Retrospective Studies
Tertiary Healthcare statistics & numerical data
Time Factors
Treatment Outcome
World Health Organization
Young Adult
Leprostatic Agents therapeutic use
Leprosy, Multibacillary drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0305-7518
- Volume :
- 84
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Leprosy review
- Publication Type :
- Academic Journal
- Accession number :
- 23741883