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Immunohistochemistry in the differential diagnostics of primary lung cancer: an investigation within the Southern Swedish Lung Cancer Study.

Authors :
Brunnström H
Johansson L
Jirström K
Jönsson M
Jönsson P
Planck M
Source :
American journal of clinical pathology [Am J Clin Pathol] 2013 Jul; Vol. 140 (1), pp. 37-46.
Publication Year :
2013

Abstract

Objectives: To assess immunohistochemical (IHC) stains differentially expressed between different types of lung cancer.<br />Methods: We evaluated 16 different IHC stains in 209 prospectively included, surgically treated primary lung cancers, including 121 adenocarcinomas, 65 squamous cell carcinomas, 15 large-cell carcinomas, 5 adenosquamous carcinomas, 2 sarcomatoid carcinomas, and 1 small-cell carcinoma, using the tissue microarray technique.<br />Results: Cytokeratin 5 (CK5) and P63 were both positive in 10% or more of the cells in 97% of the squamous cell carcinomas, with the former being positive (<10% of the cells) in only 2 non-squamous cell carcinomas. Thyroid transcription factor 1 (TTF1) and napsin A were positive in 10% or more of the cells in 88% and 87% of the adenocarcinomas, respectively, with 94% of the adenocarcinomas being positive in at least 1 marker. Fifteen percent of the adenocarcinomas were positive for estrogen receptor.<br />Conclusions: CK5, TTF1, and napsin A are sensitive markers for squamous cell carcinoma and adenocarcinoma of the lung.

Details

Language :
English
ISSN :
1943-7722
Volume :
140
Issue :
1
Database :
MEDLINE
Journal :
American journal of clinical pathology
Publication Type :
Academic Journal
Accession number :
23765532
Full Text :
https://doi.org/10.1309/AJCP50RDXSCSBTBO