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Treatment of Dirofilaria repens microfilariaemia with a combination of doxycycline hyclate and ivermectin.
- Source :
-
Veterinary parasitology [Vet Parasitol] 2013 Nov 08; Vol. 197 (3-4), pp. 702-4. Date of Electronic Publication: 2013 May 21. - Publication Year :
- 2013
-
Abstract
- Dirofilaria repens is one of the most widespread mosquito-borne filarioid responsible for infestations in dogs, usually characterized by nodules and other skin lesions. Additionally, the zoonotic potential of this nematode is of public health concern, given that D. repens has been often associated to human dirofilariosis in the Old World. In the present study, the therapeutic efficacy against D. repens microfilariae of a protocol based on doxycycline hyclate (Ronaxan(®), Merial), 10mg/kg every day for 30 days, and ivermectin (Cardotek 30(®), Merial), 6 μg/kg every 15 days for 6 months, was preliminarily investigated in two naturally infested dogs. Blood samples were collected every 30 days during 6 months of treatment and examined by a Knott's modified test and a duplex real-time PCR. The results here presented indicate that this therapeutic protocol, applied monthly, could be effective for treating microfilariaemia in dogs affected by subcutaneous dirofilariosis.<br /> (Copyright © 2013 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Anti-Bacterial Agents administration & dosage
Anti-Bacterial Agents therapeutic use
Dogs
Doxycycline administration & dosage
Drug Therapy, Combination
Female
Filaricides administration & dosage
Filaricides therapeutic use
Italy
Ivermectin administration & dosage
Male
Dirofilariasis drug therapy
Dog Diseases drug therapy
Doxycycline therapeutic use
Ivermectin therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2550
- Volume :
- 197
- Issue :
- 3-4
- Database :
- MEDLINE
- Journal :
- Veterinary parasitology
- Publication Type :
- Academic Journal
- Accession number :
- 23768566
- Full Text :
- https://doi.org/10.1016/j.vetpar.2013.05.012