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Examining the challenges of family recruitment to behavioral intervention trials: factors associated with participation and enrollment in a multi-state colonoscopy intervention trial.
- Source :
-
Trials [Trials] 2013 Apr 30; Vol. 14, pp. 116. Date of Electronic Publication: 2013 Apr 30. - Publication Year :
- 2013
-
Abstract
- Background: Colonoscopy is one of the most effective methods of cancer prevention and detection, particularly for individuals with familial risk. Recruitment of family members to behavioral intervention trials remains uniquely challenging, owing to the intensive process required to identify and contact them. Recruiting at-risk family members involves contacting the original cancer cases and asking them to provide information about their at-risk relatives, who must then be contacted for study enrollment. Though this recruitment strategy is common in family trials, few studies have compared influences of patient and relative participation to nonparticipation. Furthermore, although use of cancer registries to identify initial cases has increased, to our knowledge no study has examined the relationship between registries and family recruitment outcomes.<br />Methods: This study assessed predictors of case participation and relative enrollment in a recruitment process that utilized state cancer registries. Participation characteristics were analyzed with separate multivariable logistic regressions in three stages: (1) cancer registry-contacted colorectal cancer (CRC) cases who agreed to study contact; (2) study-contacted CRC cases who provided at-risk relative information; and (3) at-risk relatives contacted for intervention participation.<br />Results: Cancer registry source was predictive of participation for both CRC cases and relatives, though relative associations (odds ratios) varied across registries. Cases were less likely to participate if they were Hispanic or nonwhite, and were more likely to participate if they were female or younger than 50 at cancer diagnosis. At-risk relatives were more likely to participate if they were from Utah, if another family member was also participating in the study, or if they had previously had a colonoscopy. The number of eligible cases who had to be contacted to enroll one eligible relative varied widely by registry, from 7 to 81.<br />Conclusions: Family recruitment utilizing cancer registry-identified cancer cases is feasible, but highly dependent on both the strategies and protocols of those who are recruiting and on participant characteristics such as sex, race, or geography. Devising comprehensive recruitment protocols that specifically target those less likely to enroll may help future research meet recruitment goals.<br />Trial Registration: Family Colorectal Cancer Awareness and Risk Education Project NCT01274143.
- Subjects :
- Age Factors
Awareness
Chi-Square Distribution
Colonic Neoplasms economics
Colonic Neoplasms ethnology
Colonic Neoplasms genetics
Colonic Neoplasms prevention & control
Colonic Neoplasms psychology
Colonoscopy economics
Costs and Cost Analysis
Feasibility Studies
Female
Health Care Costs
Hispanic or Latino
Humans
Logistic Models
Male
Mass Screening economics
Mass Screening methods
Middle Aged
Multivariate Analysis
Odds Ratio
Patient Education as Topic
Predictive Value of Tests
Prognosis
Registries
Residence Characteristics
Risk Assessment
Risk Factors
Sex Factors
United States epidemiology
Colonic Neoplasms diagnosis
Colonoscopy psychology
Family psychology
Health Behavior ethnology
Health Knowledge, Attitudes, Practice ethnology
Mass Screening psychology
Patient Selection
Subjects
Details
- Language :
- English
- ISSN :
- 1745-6215
- Volume :
- 14
- Database :
- MEDLINE
- Journal :
- Trials
- Publication Type :
- Academic Journal
- Accession number :
- 23782890
- Full Text :
- https://doi.org/10.1186/1745-6215-14-116