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Autophagy as an immune effector against tuberculosis.
- Source :
-
Current opinion in microbiology [Curr Opin Microbiol] 2013 Jun; Vol. 16 (3), pp. 355-65. Date of Electronic Publication: 2013 Jun 18. - Publication Year :
- 2013
-
Abstract
- The now well-accepted innate immunity paradigm that autophagy acts as a cell-autonomous defense against intracellular bacteria has its key origins in studies with Mycobacterium tuberculosis, an important human pathogen and a model microorganism infecting macrophages. A number of different factors have been identified that play into the anti-mycobacterial functions of autophagy, and recent in vivo studies in the mouse model of tuberculosis have uncovered additional anti-inflammatory and tissue-sparing functions of autophagy. Complementing these observations, genome wide association studies indicate a considerable overlap between autophagy, human susceptibility to mycobacterial infections and predisposition loci for inflammatory bowel disease. Finally, recent studies show that autophagy is an important regulator and effector of IL-1 responses, and that autophagy intersects with type I interferon pathology-modulating responses.<br /> (Copyright © 2013 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1879-0364
- Volume :
- 16
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Current opinion in microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 23790398
- Full Text :
- https://doi.org/10.1016/j.mib.2013.05.003