Back to Search
Start Over
The role of CYP2C8 genotypes in dose requirement and levels of everolimus after heart transplantation.
The role of CYP2C8 genotypes in dose requirement and levels of everolimus after heart transplantation.
- Source :
-
Wiener klinische Wochenschrift [Wien Klin Wochenschr] 2013 Jul; Vol. 125 (13-14), pp. 393-5. - Publication Year :
- 2013
-
Abstract
- Everolimus is an immunosuppressive drug metabolized by enzymes of the CYP family. A common variant of the CYP2C8 gene, CYP2C8*3, results in strongly decreased CYP2C8 activity, but its role for the pharmacogenetics of everolimus remains unclear. Aim of the present study was to examine the role of CYP2C8 variants in everolimus dose and drug levels after heart transplantation. The present study comprised 30 patients with everolimus based maintenance therapy after heart transplantation. CYP2C8 genotypes were determined and correlated with clinical data. In all, 21 subjects carried the CYP2C8 *1/*1 genotype and 9 subjects carried the CYP2C8 *1/*3 genotype. Neither everolimus dose nor everolimus levels were associated with CYP2C8 genotype at any point of time (pā<ā0.05). During follow-up, graft rejection reactions were observed in two patients and infections were observed in seven patients. In one patient, type 2 diabetes was diagnosed during follow-up. None of these adverse events were significantly associated with CYP2C8 genotypes. We conclude that in adult patients after heart transplantation, CYP2C8 genotypes are not associated with dose requirements or levels of everolimus.
- Subjects :
- Cytochrome P-450 CYP2C8
Dose-Response Relationship, Drug
Everolimus
Female
Genotype
Graft Rejection diagnosis
Humans
Immunosuppressive Agents adverse effects
Immunosuppressive Agents blood
Male
Pharmacogenetics methods
Sirolimus blood
Sirolimus therapeutic use
Treatment Outcome
Aryl Hydrocarbon Hydroxylases blood
Aryl Hydrocarbon Hydroxylases genetics
Graft Rejection blood
Graft Rejection prevention & control
Heart Transplantation adverse effects
Sirolimus analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1613-7671
- Volume :
- 125
- Issue :
- 13-14
- Database :
- MEDLINE
- Journal :
- Wiener klinische Wochenschrift
- Publication Type :
- Academic Journal
- Accession number :
- 23797529
- Full Text :
- https://doi.org/10.1007/s00508-013-0387-2