Back to Search
Start Over
Brain 3-Mercaptopyruvate Sulfurtransferase (3MST): Cellular Localization and Downregulation after Acute Stroke.
- Source :
-
PloS one [PLoS One] 2013 Jun 21; Vol. 8 (6), pp. e67322. Date of Electronic Publication: 2013 Jun 21 (Print Publication: 2013). - Publication Year :
- 2013
-
Abstract
- 3-Mercaptopyruvate sulfurtransferase (3MST) is an important enzyme for the synthesis of hydrogen sulfide (H2S) in the brain. We present here data that indicate an exclusively localization of 3MST in astrocytes. Regional distribution of 3MST activities is even and unremarkable. Following permanent middle cerebral artery occlusion (pMCAO), 3MST was down-regulated in both the cortex and striatum, but not in the corpus collosum. It appears that the down-regulation of astrocytic 3MST persisted in the presence of astrocytic proliferation due to gliosis. Our observations indicate that 3MST is probably not responsible for the increased production of H2S following pMCAO. Therefore, cystathionine β-synthase (CBS), the alternative H2S producing enzyme in the CNS, remains as a more likely potential therapeutic target than 3MST in the treatment of acute stroke through inhibition of H2S production.
- Subjects :
- Animals
Astrocytes pathology
Cerebral Cortex pathology
Corpus Callosum enzymology
Corpus Callosum pathology
Corpus Striatum pathology
Hydrogen Sulfide metabolism
Male
Rats
Rats, Sprague-Dawley
Stroke pathology
Astrocytes enzymology
Cerebral Cortex enzymology
Corpus Striatum enzymology
Down-Regulation
Gene Expression Regulation, Enzymologic
Stroke enzymology
Sulfurtransferases biosynthesis
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 8
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 23805308
- Full Text :
- https://doi.org/10.1371/journal.pone.0067322