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RTEL1 and TERT polymorphisms are associated with astrocytoma risk in the Chinese Han population.
- Source :
-
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine [Tumour Biol] 2013 Dec; Vol. 34 (6), pp. 3659-66. Date of Electronic Publication: 2013 Jun 29. - Publication Year :
- 2013
-
Abstract
- Common variants of multiple genes play a role in glioma onset. However, research related to astrocytoma, the most common primary brain neoplasm, is rare. In this study, we chose 21 tagging SNPs (tSNPs), previously reported to be associated with glioma risk in a Chinese case-control study from Xi'an, China, and identified their contributions to astrocytoma susceptibility. We found an association with astrocytoma susceptibility for two tSNPs (rs6010620 and rs2853676) in two different genes: regulator of telomere elongation helicase 1 (RTEL1) and telomerase reverse transcriptase (TERT), respectively. We confirmed our results using recessive, dominant, and additive models. In the recessive model, we found two tSNPs (rs2297440 and rs6010620) associated with increased astrocytoma risk. In the dominant model, we found that rs2853676 was associated with increased astrocytoma risk. In the additive model, all three tSNPs (rs2297440, rs2853676, and rs6010620) were associated with increased astrocytoma risk. Our results demonstrate, for the first time, the potential roles of RTEL1 and TERT in astrocytoma development.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Asian People genetics
Astrocytoma ethnology
Brain Neoplasms ethnology
Case-Control Studies
Child
Child, Preschool
China
Female
Gene Frequency
Genetic Predisposition to Disease ethnology
Genotype
Humans
Infant
Male
Middle Aged
Odds Ratio
Risk Factors
Young Adult
Astrocytoma genetics
Brain Neoplasms genetics
DNA Helicases genetics
Genetic Predisposition to Disease genetics
Polymorphism, Single Nucleotide
Telomerase genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1423-0380
- Volume :
- 34
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 23812731
- Full Text :
- https://doi.org/10.1007/s13277-013-0947-0