Back to Search
Start Over
Re-evaluation of ABO gene polymorphisms detected in a genome-wide association study and risk of pancreatic ductal adenocarcinoma in a Chinese population.
- Source :
-
Chinese journal of cancer [Chin J Cancer] 2014 Feb; Vol. 33 (2), pp. 68-73. Date of Electronic Publication: 2013 Jul 02. - Publication Year :
- 2014
-
Abstract
- Pancreatic cancer is a fatal malignancy with an increasing incidence in Shanghai, China. A genome-wide association study (GWAS) and other work have shown that ABO alleles are associated with pancreatic cancer risk. We conducted a population-based case-control study involving 256 patients with pathologically confirmed pancreatic ductal adenocarcinoma (PDAC) and 548 healthy controls in Shanghai, China, to assess the relationships between GWAS-identified ABO alleles and risk of PDAC. Carriers of the C allele of rs505922 had an increased cancer risk [adjusted odds ratio (OR) = 1.42, 95% confidence interval (CI): 1.02-1.98] compared to TT carriers. The T alleles of rs495828 and rs657152 were also significantly associated with an elevated cancer risk (adjusted OR = 1.58, 95% CI: 1.17-2.14; adjusted OR = 1.51, 95% CI: 1.09-2.10). The rs630014 variant was not associated with risk. We did not find any significant gene-environment interaction with cancer risk using a multifactor dimensionality reduction (MDR) method. Haplotype analysis also showed that the haplotype CTTC was associated with an increased risk of PDAC (adjusted OR = 1.46, 95% CI: 1.12-1.91) compared with haplotype TGGT. GWAS-identified ABO variants are thus also associated with risk of PDAC in the Chinese population.
- Subjects :
- Aged
Alleles
Asian People genetics
Case-Control Studies
China
Confidence Intervals
Female
Gene-Environment Interaction
Genome-Wide Association Study
Genotype
Haplotypes
Humans
Male
Middle Aged
Odds Ratio
Polymorphism, Single Nucleotide
Risk Factors
ABO Blood-Group System genetics
Adenocarcinoma genetics
Pancreatic Neoplasms genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1000-467X
- Volume :
- 33
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Chinese journal of cancer
- Publication Type :
- Academic Journal
- Accession number :
- 23816557
- Full Text :
- https://doi.org/10.5732/cjc.013.10060