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Association between severe obstructive sleep apnea and incident arterial hypertension in the older people population.

Authors :
Guillot M
Sforza E
Achour-Crawford E
Maudoux D
Saint-Martin M
Barthélémy JC
Roche F
Source :
Sleep medicine [Sleep Med] 2013 Sep; Vol. 14 (9), pp. 838-42. Date of Electronic Publication: 2013 Jul 03.
Publication Year :
2013

Abstract

Objectives: The impact of sleep-related breathing disorders on the incidence of arterial hypertension (AHT) in the older adults is not well-established. The aim of our study was to test the link between severe obstructive sleep apnea (OSA) and the occurrence of hypertension in older subjects after 3 years.<br />Methods: 372 normotensive subjects with a mean age of 68.2 years were included in our longitudinal study. All participants had a ventilatory polygraphic recording and an ambulatory blood pressure (BP) monitoring at baseline and after 3 years. Severe OSA was defined by an apnea-hypopnea index (AHI) of ≥ P30 per hour. A new onset of hypertension was defined according to a mean 24-hour value >140mmHg for systolic BP and >85mmHg for diastolic BP or the use of antihypertensive medication.<br />Results: The baseline factors significantly associated with an increased risk for new-onset hypertension were male gender, obesity, diabetes mellitus (DM), dyslipidemia, and OSA. Multiple logistic regression analyses showed that an AHI ≥30 per hour was independently associated with incident hypertension after 3 years (P=.02; odds ratio [OR], 1.8; 95% confidence interval [CI], 1.1-2.8).<br />Conclusions: The presence of severe OSA is associated with new-onset AHT in normotensive elderly (mean age, 68.2 y) subjects.<br /> (Copyright © 2013 Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
1878-5506
Volume :
14
Issue :
9
Database :
MEDLINE
Journal :
Sleep medicine
Publication Type :
Academic Journal
Accession number :
23831239
Full Text :
https://doi.org/10.1016/j.sleep.2013.05.002