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Clinical features and sera anti-aquaporin 4 antibody positivity in patients with demyelinating disorders of the central nervous system from Tianjin, China.
- Source :
-
CNS neuroscience & therapeutics [CNS Neurosci Ther] 2014 Jan; Vol. 20 (1), pp. 32-9. Date of Electronic Publication: 2013 Jul 27. - Publication Year :
- 2014
-
Abstract
- Aims: To investigate the clinical characteristics and sera anti-aquaporin 4 (AQP4) antibody positivity in patients with inflammatory demyelinating disorders (IDDs) of the central nervous system (CNS) in Tianjin, China.<br />Methods: We retrospectively evaluated 234 patients with IDDs including neuromyelitis optica (NMO), recurrent optic neuritis (rON), longitudinally extensive transverse myelitis (LETM), clinically isolated syndrome (CIS), and multiple sclerosis (MS) groups. Sera from 217 patients were determined for AQP4-Ab. The clinical characteristics and sera anti-AQP4 positivity were compared.<br />Results: The IDDS comprised 63 MS, 51 NMO, 56 LETM, 10 rON, and 54 CIS. Compared with MS, NMO had a higher frequency of occurrence in women, intractable hiccup and nausea (IHN), medullospinal lesion, longitudinally extensive spinal cord lesions (LESCL) and bilateral ON, disease onset at a later age, and worsening residual disability. AQP4-Ab-positive rates were 84.1% and 69% in NMO and NMO spectrum disorders (NMOSD), respectively, whereas it was undetectable in all of the MS sera samples.<br />Conclusions: We comprehensively contrast the distinct clinical features of MS, NMO, and NMOSD in our center. A sensitive AQP4-Ab assay is necessary for the early diagnosis of NMOSD in our patients. Neither medullospinal lesion nor IHN is unique in NMO.<br /> (© 2013 John Wiley & Sons Ltd.)
- Subjects :
- Adolescent
Adult
Aged
Brain pathology
China epidemiology
Demyelinating Autoimmune Diseases, CNS pathology
Demyelinating Diseases pathology
Female
HEK293 Cells
Humans
Male
Middle Aged
Multiple Sclerosis epidemiology
Multiple Sclerosis immunology
Multiple Sclerosis pathology
Myelitis, Transverse epidemiology
Myelitis, Transverse immunology
Myelitis, Transverse pathology
Neuromyelitis Optica epidemiology
Neuromyelitis Optica immunology
Neuromyelitis Optica pathology
Optic Neuritis epidemiology
Optic Neuritis immunology
Optic Neuritis pathology
Retrospective Studies
Spinal Cord pathology
Young Adult
Aquaporin 4 immunology
Autoantibodies blood
Demyelinating Autoimmune Diseases, CNS epidemiology
Demyelinating Autoimmune Diseases, CNS immunology
Demyelinating Diseases epidemiology
Demyelinating Diseases immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1755-5949
- Volume :
- 20
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- CNS neuroscience & therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 23890015
- Full Text :
- https://doi.org/10.1111/cns.12156