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Potential interest of a new absorbable collagen membrane in the prevention of adhesions in paediatric cardiac surgery: a feasibility study.
- Source :
-
Archives of cardiovascular diseases [Arch Cardiovasc Dis] 2013 Aug-Sep; Vol. 106 (8-9), pp. 433-9. Date of Electronic Publication: 2013 Jul 29. - Publication Year :
- 2013
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Abstract
- Background: Open-heart surgery can result in adhesions, which can complicate resternotomy.<br />Aims: To document the occurrence of adhesions after the use of a new collagen membrane; to evaluate its tolerability; and to compare surgical parameters with control patients.<br />Methods: Paediatric patients who underwent cardiac surgery with the collagen membrane (Cova™ CARD; Biom'up, Saint Priest, France) were analysed retrospectively for levels of adhesion and tolerability. The times of dissection and intervention and the transfusion of packed red blood cells and haemostatic products were compared to a historic cohort who did not receive an anti-adhesion device.<br />Results: From January 2010 to December 2011, 36 patients received a collagen membrane. Nineteen re-interventions were performed, after a mean of 169 days. No grade 3 adhesions were observed and no tolerability problems were reported. During re-interventions after more than 30 days, the propensity score-adjusted durations of dissection and the total process for patients with and without a collagen membrane were 32 vs 41 minutes and 151 vs 182 minutes, respectively (not significant). The mean quantities of red blood cells and biological glue administered in the two groups were 98 vs 139 mL and 1.2 vs 0.5 mL, respectively (not significant).<br />Conclusions: This feasibility study shows the potential use of the new membrane in paediatric patients, both in terms of prevention from severe adherence and tolerability. This is the first study of this membrane in humans. A prospective, controlled study is necessary to provide strong evidence of its efficiency.<br /> (Copyright © 2013 Elsevier Masson SAS. All rights reserved.)
- Subjects :
- Adolescent
Age Factors
Child
Child, Preschool
Collagen adverse effects
Erythrocyte Transfusion
Feasibility Studies
Female
Hemostatics therapeutic use
Humans
Infant
Male
Operative Time
Reoperation
Retrospective Studies
Time Factors
Tissue Adhesives therapeutic use
Treatment Outcome
Absorbable Implants
Biocompatible Materials
Cardiac Surgical Procedures adverse effects
Collagen therapeutic use
Tissue Adhesions prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1875-2128
- Volume :
- 106
- Issue :
- 8-9
- Database :
- MEDLINE
- Journal :
- Archives of cardiovascular diseases
- Publication Type :
- Academic Journal
- Accession number :
- 23906681
- Full Text :
- https://doi.org/10.1016/j.acvd.2013.05.003