Back to Search Start Over

Fragrance material review on acetyl cedrene.

Authors :
Scognamiglio J
Letizia CS
Politano VT
Api AM
Source :
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2013 Dec; Vol. 62 Suppl 1, pp. S152-66. Date of Electronic Publication: 2013 Jul 29.
Publication Year :
2013

Abstract

A toxicologic and dermatologic review of acetyl cedrene when used as a fragrance ingredient is presented. Acetyl cedrene is a member of the fragrance structural group Alkyl Cyclic Ketones. The generic formula for this group can be represented as (R1)(R2)CO. These fragrances can be described as being composed of an alkyl, R1, and various substituted and bicyclic saturated or unsaturated cyclic hydrocarbons, R2, in which one of the rings may include up to 12 carbons. Alternatively, R2 may be a carbon bridge of C2-C4 carbon chain length between the ketone and cyclic hydrocarbon. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for acetyl cedrene were evaluated then summarized and includes physical properties, acute toxicity, skin irritation, mucous membrane (eye) irritation, skin sensitization, elicitation, phototoxicity, photoallergy, toxicokinetics, repeated dose, reproductive toxicity, and genotoxicity data. A safety assessment of the entire Alkyl Cyclic Ketones will be published simultaneously with this document; please refer to Belsito et al. (2013) (Belsito, D., Bickers, D., Bruze, M., Calow, P., Dagli, M., Fryer, A.D., Greim, H., Miyachi, Y., Saurat, J.H., Sipes, I.G., 2013. A Toxicologic and Dermatologic Assessment of Alkyl Cyclic Ketones When Used as Fragrance Ingredients. Submitted with this manuscript.) for an overall assessment of the safe use of this material and all Alkyl Cyclic Ketones in fragrances.<br /> (Copyright © 2013. Published by Elsevier Ltd.)

Details

Language :
English
ISSN :
1873-6351
Volume :
62 Suppl 1
Database :
MEDLINE
Journal :
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Publication Type :
Academic Journal
Accession number :
23907023
Full Text :
https://doi.org/10.1016/j.fct.2013.07.053