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Fragrance material review on acetyl cedrene.
- Source :
-
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2013 Dec; Vol. 62 Suppl 1, pp. S152-66. Date of Electronic Publication: 2013 Jul 29. - Publication Year :
- 2013
-
Abstract
- A toxicologic and dermatologic review of acetyl cedrene when used as a fragrance ingredient is presented. Acetyl cedrene is a member of the fragrance structural group Alkyl Cyclic Ketones. The generic formula for this group can be represented as (R1)(R2)CO. These fragrances can be described as being composed of an alkyl, R1, and various substituted and bicyclic saturated or unsaturated cyclic hydrocarbons, R2, in which one of the rings may include up to 12 carbons. Alternatively, R2 may be a carbon bridge of C2-C4 carbon chain length between the ketone and cyclic hydrocarbon. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for acetyl cedrene were evaluated then summarized and includes physical properties, acute toxicity, skin irritation, mucous membrane (eye) irritation, skin sensitization, elicitation, phototoxicity, photoallergy, toxicokinetics, repeated dose, reproductive toxicity, and genotoxicity data. A safety assessment of the entire Alkyl Cyclic Ketones will be published simultaneously with this document; please refer to Belsito et al. (2013) (Belsito, D., Bickers, D., Bruze, M., Calow, P., Dagli, M., Fryer, A.D., Greim, H., Miyachi, Y., Saurat, J.H., Sipes, I.G., 2013. A Toxicologic and Dermatologic Assessment of Alkyl Cyclic Ketones When Used as Fragrance Ingredients. Submitted with this manuscript.) for an overall assessment of the safe use of this material and all Alkyl Cyclic Ketones in fragrances.<br /> (Copyright © 2013. Published by Elsevier Ltd.)
- Subjects :
- Animals
Consumer Product Safety
Dermatitis, Photoallergic etiology
Dermatitis, Phototoxic etiology
Drug Hypersensitivity etiology
Eye drug effects
Humans
Irritants toxicity
Perfume toxicity
Sesquiterpenes chemistry
Sesquiterpenes pharmacokinetics
Toxicity Tests
Perfume chemistry
Sesquiterpenes toxicity
Skin drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1873-6351
- Volume :
- 62 Suppl 1
- Database :
- MEDLINE
- Journal :
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
- Publication Type :
- Academic Journal
- Accession number :
- 23907023
- Full Text :
- https://doi.org/10.1016/j.fct.2013.07.053