Back to Search
Start Over
Antihypertensive medication use and risk of cognitive impairment: the Honolulu-Asia Aging Study.
- Source :
-
Neurology [Neurology] 2013 Sep 03; Vol. 81 (10), pp. 888-95. Date of Electronic Publication: 2013 Aug 02. - Publication Year :
- 2013
-
Abstract
- Objective: To determine the associations between classes of antihypertensive medication use and the risk of cognitive impairment among elderly hypertensive men.<br />Methods: The Honolulu-Asia Aging Study is a prospective, community-based cohort study of Japanese American men conducted in Honolulu, Hawaii. We examined 2,197 participants (mean age 77 years at cohort entry, 1991-1993, followed through September 2010) with hypertension and without dementia or cognitive impairment at baseline, who provided information on medication use. Cognitive function was assessed at 7 standardized examinations using the Cognitive Abilities Screening Instrument (CASI). Cognitive impairment was defined as a CASI score <74.<br />Results: A total of 854 men developed cognitive impairment (median follow-up, 5.8 years). β-Blocker use as the sole antihypertensive drug at baseline was consistently associated with a lower risk of cognitive impairment (incidence rate ratio [IRR] 0.69; 95% confidence interval [CI] 0.50-0.94), as compared with men not taking any antihypertensive medications, adjusting for multiple potential confounders. The use of diuretics, calcium channel blockers, angiotensin-converting enzyme inhibitors, or vasodilators alone was not significantly associated with cognitive impairment. Results were similar excluding those with cardiovascular disease or <1 year of follow-up, and additionally adjusting for pulse pressure, heart rate, baseline and midlife systolic blood pressure, and midlife antihypertensive treatment (IRR 0.65; 95% CI 0.45-0.94). The association between β-blocker use and cognitive impairment was stronger among men with diabetes, men aged >75 years, and those with pulse pressure ≥70 mm Hg.<br />Conclusions: β-blocker use is associated with a lower risk of developing cognitive impairment in elderly Japanese American men.
- Subjects :
- Aged
Aged, 80 and over
Aging drug effects
Aging psychology
Asia ethnology
Cognition Disorders prevention & control
Cognition Disorders psychology
Cohort Studies
Follow-Up Studies
Hawaii ethnology
Humans
Hypertension drug therapy
Hypertension psychology
Male
Prospective Studies
Risk Factors
Adrenergic beta-Antagonists therapeutic use
Aging ethnology
Antihypertensive Agents therapeutic use
Asian ethnology
Cognition Disorders ethnology
Hypertension ethnology
Subjects
Details
- Language :
- English
- ISSN :
- 1526-632X
- Volume :
- 81
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Neurology
- Publication Type :
- Academic Journal
- Accession number :
- 23911753
- Full Text :
- https://doi.org/10.1212/WNL.0b013e3182a351d4