Back to Search
Start Over
Long-term outcome of young onset Parkinson's disease after subthalamic stimulation--a cross-sectional study.
- Source :
-
Clinical neurology and neurosurgery [Clin Neurol Neurosurg] 2013 Oct; Vol. 115 (10), pp. 2082-7. Date of Electronic Publication: 2013 Aug 03. - Publication Year :
- 2013
-
Abstract
- Objective: Age of onset is considered a poor prognostic factor for subthalamic deep brain stimulation (STN-DBS) outcome in the case of Parkinson's disease (PD). The goal of current study is to identify the long-term impact of STN-DBS for young onset PD (YOPD) patients.<br />Methods: 17 YOPD patients with a mean disease onset at 32.3 years were prospectively followed up at 1, 2, 5 and 7 years after STN-DBS. Unified Parkinson's disease rating scale (UPDRS) was evaluated in 4 combinations of Med/DBS on/off.<br />Results: UPDRS part II-IV improved significantly 7 years after operation. While a slowly progressive worsening of levodopa response on part III, synergistic effect of medication and stimulation consistently improves motor disabilities. STN-DBS could remarkably reduce levodopa equivalent daily dose at 7 years. The morbidity rates were low. However, these patients seem to have more transient stimulation dyskinesia (47.1%) and dopamine dysregulation syndrome (11.8%) after surgery.<br />Conclusions: STN-DBS remains effective to improve motor disabilities over 7 years for YOPD and is a safe procedure concerning cognitive outcome and morbidity. However, stimulation dyskinesia and dopamine dysregulation syndrome deserve attention for the causal relationship between DBS surgery and behavioral outcomes.<br /> (Copyright © 2013 Elsevier B.V. All rights reserved.)
- Subjects :
- Activities of Daily Living
Adult
Age of Onset
Antiparkinson Agents therapeutic use
Cognition physiology
Cohort Studies
Cross-Sectional Studies
Female
Follow-Up Studies
Humans
Levodopa therapeutic use
Male
Mental Disorders epidemiology
Mental Disorders etiology
Mental Disorders therapy
Middle Aged
Movement Disorders epidemiology
Movement Disorders etiology
Movement Disorders therapy
Parkinson Disease drug therapy
Prognosis
Treatment Outcome
Deep Brain Stimulation methods
Parkinson Disease therapy
Subthalamic Nucleus physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-6968
- Volume :
- 115
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Clinical neurology and neurosurgery
- Publication Type :
- Academic Journal
- Accession number :
- 23916724
- Full Text :
- https://doi.org/10.1016/j.clineuro.2013.07.014