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The difficulty in defining extended donor criteria for liver grafts: the Eurotransplant experience.
- Source :
-
Transplant international : official journal of the European Society for Organ Transplantation [Transpl Int] 2013 Oct; Vol. 26 (10), pp. 990-8. Date of Electronic Publication: 2013 Aug 10. - Publication Year :
- 2013
-
Abstract
- Donor criteria for liver grafts have been expanded because of organ shortage. Currently, no exact definitions for extended donor grafts have been established. The aim of this study was to analyze the impact of donor-specific risk factors, independent of recipient characteristics. In collaboration with Eurotransplant and European Liver Transplant Register, solely donor-specific parameters were correlated with 1-year survival following liver transplantation. Analyses of 4701 donors between 2000 and 2005 resulted in the development of a nomogram to estimate graft survival for available grafts. Predictions by nomogram were compared to those by Donor Risk Index (DRI). In the multivariate analysis, cold ischemic time (CIT), highest sodium, cause of donor death, γ-glutamyl transferase (γ-GT), and donor sex (female) were statistically significant factors for 3 months; CIT, γ-GT, and cause of donor death for 12-month survival. The median DRI of this study population was 1.45 (Q1: 1.17; Q3: 1.67). The agreement between the nomogram and DRI was weak (kappa = 0.23). Several donor-specific risk factors were identified for early survival after liver transplantation. The provided nomogram will support quick organ quality assessment. Nevertheless, this study showed the difficulties of determining an exact definition of extended criteria donors.<br /> (© 2013 Steunstichting ESOT. Published by John Wiley & Sons Ltd.)
- Subjects :
- Adult
Cold Ischemia
Europe
Female
Graft Survival
Humans
Liver Failure mortality
Liver Failure therapy
Male
Middle Aged
Multivariate Analysis
Nomograms
Registries
Risk Factors
Sex Factors
Treatment Outcome
Waiting Lists
gamma-Glutamyltransferase metabolism
Liver Transplantation methods
Liver Transplantation standards
Tissue Donors
Tissue and Organ Procurement standards
Subjects
Details
- Language :
- English
- ISSN :
- 1432-2277
- Volume :
- 26
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Transplant international : official journal of the European Society for Organ Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 23931659
- Full Text :
- https://doi.org/10.1111/tri.12156