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Effect of taxane-based neoadjuvant chemotherapy on fibroglandular tissue volume and percent breast density in the contralateral normal breast evaluated by 3T MR.
- Source :
-
NMR in biomedicine [NMR Biomed] 2013 Dec; Vol. 26 (12), pp. 1705-13. Date of Electronic Publication: 2013 Aug 12. - Publication Year :
- 2013
-
Abstract
- The aim of this study was to evaluate the change of breast density in the normal breast of patients receiving neoadjuvant chemotherapy (NAC). Forty-four breast cancer patients were studied. MRI acquisition was performed before treatment (baseline), and 4 and 12 weeks after treatment. A computer-algorithm-based program was used to segment breast tissue and calculate breast volume (BV), fibroglandular tissue volume (FV), and percent density (PD) (the ratio of FV over BV × 100%). The reduction of FV and PD after treatment was compared with baseline using paired t-tests with a Bonferroni-Holm correction. The association of density reduction with age was analyzed. FV and PD after NAC showed significant decreases compared with the baseline. FV was 110.0 ml (67.2, 189.8) (geometric mean (interquartile range)) at baseline, 104.3 ml (66.6, 164.4) after 4 weeks (p < 0.0001), and 94.7 ml (60.2, 144.4) after 12 weeks (comparison with baseline, p < 0.0001; comparison with 4 weeks, p = 0.016). PD was 11.2% (6.4, 22.4) at baseline, 10.6% (6.6, 20.3) after 4 weeks (p < 0.0001), and 9.7% (6.2, 17.9) after 12 weeks (comparison with baseline, p = 0.0001; comparison with 4 weeks, p = 0.018). Younger patients tended to show a higher density reduction, but overall correlation with age was only moderate (r = 0.28 for FV, p = 0.07, and r = 0.52 for PD, p = 0.0003). Our study showed that breast density measured from MR images acquired at 3T MR can be accurately quantified using a robust computer-aided algorithm based on non-parametric non-uniformity normalization (N3) and an adaptive fuzzy C-means algorithm. Similar to doxorubicin and cyclophosphamide regimens, the taxane-based NAC regimen also caused density atrophy in the normal breast and showed reduction in FV and PD. The effect of breast density reduction was age related and duration related.<br /> (Copyright © 2013 John Wiley & Sons, Ltd.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Biomarkers, Tumor metabolism
Breast drug effects
Bridged-Ring Compounds pharmacology
Female
Humans
Middle Aged
Organ Size drug effects
Taxoids pharmacology
Breast pathology
Breast Neoplasms drug therapy
Bridged-Ring Compounds therapeutic use
Magnetic Resonance Imaging
Neoadjuvant Therapy
Taxoids therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1099-1492
- Volume :
- 26
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- NMR in biomedicine
- Publication Type :
- Academic Journal
- Accession number :
- 23940080
- Full Text :
- https://doi.org/10.1002/nbm.3006