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BH3 helix-derived biophotonic nanoswitches regulate cytochrome c release in permeabilised cells.
- Source :
-
Molecular bioSystems [Mol Biosyst] 2013 Nov; Vol. 9 (11), pp. 2597-603. - Publication Year :
- 2013
-
Abstract
- Dynamic physical interactions between proteins underpin all key cellular processes and are a highly attractive area for the development of research tools and medicines. Protein-protein interactions frequently involve α-helical structures, but peptides matching the sequences of these structures usually do not fold correctly in isolation. Therefore, much research has focused on the creation of small peptides that adopt stable α-helical structures even in the absence of their intended protein targets. We show that short peptides alkylated with azobenzene crosslinkers can be used to photo-stimulate mitochondrial membrane depolarization and cytochrome c release in permeabilised cells, the initial events of the intrinsic apoptosis pathway.
- Subjects :
- Alkylation drug effects
Amino Acid Sequence
Azo Compounds chemistry
Azo Compounds pharmacology
Cell Line, Tumor
Humans
Mitochondria drug effects
Mitochondria metabolism
Peptide Fragments chemistry
Protein Structure, Secondary
Proto-Oncogene Proteins chemistry
Cytochromes c metabolism
Peptide Fragments pharmacology
Proto-Oncogene Proteins pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1742-2051
- Volume :
- 9
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Molecular bioSystems
- Publication Type :
- Academic Journal
- Accession number :
- 23942570
- Full Text :
- https://doi.org/10.1039/c3mb70246d