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The kinase-independent, second life of CDK6 in transcription.
- Source :
-
Cancer cell [Cancer Cell] 2013 Aug 12; Vol. 24 (2), pp. 141-3. - Publication Year :
- 2013
-
Abstract
- CDK6 is an oncogenic kinase regulating the cell cycle. In this issue of Cancer Cell, Kollmann and colleagues demonstrate that CDK6 performs a kinase-independent transcriptional function in regulating expression of VEGF-A and p16INK4a. These observations link the cell cycle machinery and angiogenesis and reveal the presence of a fail-safe antiproliferative mechanism.<br /> (Copyright © 2013 Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1878-3686
- Volume :
- 24
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Cancer cell
- Publication Type :
- Academic Journal
- Accession number :
- 23948293
- Full Text :
- https://doi.org/10.1016/j.ccr.2013.07.019