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Neuroanatomical basis for acupuncture point PC8 in the rat: neural tracing study with cholera toxin subunit B.
- Source :
-
Acupuncture in medicine : journal of the British Medical Acupuncture Society [Acupunct Med] 2013 Dec; Vol. 31 (4), pp. 389-94. Date of Electronic Publication: 2013 Aug 16. - Publication Year :
- 2013
-
Abstract
- Objectives: This study was performed to investigate the innervations related to acupuncture point PC8 in rats using a neural tracing technique.<br />Methods: After 6 μL of 1% cholera toxin subunit B (CTB) was injected into the site between the second and third metacarpal bone in rats, a corresponding site to acupuncture point PC8 in the human body, CTB labelling was examined with immunofluorescence and immunohistochemistry in the dorsal root ganglia (DRG), spinal cord and brainstem.<br />Results: All CTB labelling appeared on the ipsilateral side of the injection. The labelled sensory neurons distributed from cervical (C)6 to thoracic (T)1 DRG, while the labelled motor neurons were located on the dorsolateral part of the spinal ventral horn ranging from the C6 to T1 segments. In addition, the transganglionically-labelled axonal terminals were found to be dense in the medial part of laminae 3-4 from C6 to the T1 spinal dorsal horn, as far as in the cuneate nucleus.<br />Conclusions: These results indicate that sensory and motor neurons associated with PC8 distribute in a distinct segmental pattern. The sensory information from PC8 could be transganglionically transported to the spinal dorsal horn and cuneate nucleus.
- Subjects :
- Animals
Cholera Toxin chemistry
Ganglia, Spinal anatomy & histology
Ganglia, Spinal chemistry
Ganglia, Spinal metabolism
Male
Motor Neurons chemistry
Motor Neurons metabolism
Neuroanatomy
Rats
Rats, Sprague-Dawley
Sensory Receptor Cells chemistry
Sensory Receptor Cells metabolism
Spinal Cord anatomy & histology
Spinal Cord chemistry
Spinal Cord metabolism
Staining and Labeling
Acupuncture Points
Cholera Toxin metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1759-9873
- Volume :
- 31
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Acupuncture in medicine : journal of the British Medical Acupuncture Society
- Publication Type :
- Academic Journal
- Accession number :
- 23956381
- Full Text :
- https://doi.org/10.1136/acupmed-2013-010400