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[Predicting early response to immunosuppressive therapy in severe aplastic anemia by soluble transferrin receptor assay].
- Source :
-
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi [Zhonghua Xue Ye Xue Za Zhi] 2013 Aug; Vol. 34 (8), pp. 709-13. - Publication Year :
- 2013
-
Abstract
- Objective: To evaluate the value of serum soluble transferrin receptor (sTfR) concentration in predicting early response to immunosuppressive therapy (IST) in severe aplastic anemia (SAA).<br />Methods: Clinical data and hematologic responses of 140 SAA patients treated with rabbit antithymocyte globulin (rATG) combination with cyclosporine in our hospital were retrospectively analyzed. Correlation of pre-IST baseline of sTfR and IST responses was statistically analyzed and receiver operating characteristic (ROC) curve was used to estimate the sensitivity and specificity of sTfR in prediction of early responses.<br />Results: Serum concentration of sTfR in very SAA (VSAA) patients were significantly lower than SAA and transfusion dependent non-SAA cases (P=0.001). The responders, especially at 3 months, had significantly higher pre- IST baseline of sTfR [median, 0.89 (range, 0.21-2.42) mg/L] than that [median, 0.58 (range, 0.13-1.88) mg/L] of non-responders (P=0.005). The cutoff level of 0.91 mg/L and 0.88 mg/L for predicting responses at 3 and 6 months were established based on the ROC curve, with the degree of accuracy of 65.0% and 60.7% respectively. Multivariate analysis showed that pre-IST baseline of sTfR was the independent factor of predicting response at 3 months (P=0.007) and at 6 months (P=0.021).<br />Conclusion: As a indicator of bone marrow failure severity, sTfR could predict early response to IST therapy in aplastic anemia.
- Subjects :
- Adolescent
Adult
Aged
Antilymphocyte Serum therapeutic use
Child
Child, Preschool
Cyclosporine therapeutic use
Female
Humans
Male
Middle Aged
Receptors, Transferrin immunology
Retrospective Studies
Sensitivity and Specificity
Treatment Outcome
Young Adult
Anemia, Aplastic therapy
Immunosuppression Therapy
Receptors, Transferrin therapeutic use
Subjects
Details
- Language :
- Chinese
- ISSN :
- 0253-2727
- Volume :
- 34
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
- Publication Type :
- Academic Journal
- Accession number :
- 23978026
- Full Text :
- https://doi.org/10.3760/cma.j.issn.0253-2727.2013.08.015