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β-Arrestin 2 mediates G protein-coupled receptor 43 signals to nuclear factor-κB.
- Source :
-
Biological & pharmaceutical bulletin [Biol Pharm Bull] 2013; Vol. 36 (11), pp. 1754-9. Date of Electronic Publication: 2013 Aug 29. - Publication Year :
- 2013
-
Abstract
- G-protein coupled receptor 43 (GPR43) serves as a receptor for short-chain fatty acids (SCFAs), implicated in neutrophil migration and inflammatory cytokine production. However, the intracellular signaling pathway mediating GPR43 signaling remains unclear. Here, we show that β-arrestin 2 mediates the internalization of GPR43 by agonist. Agonism of GPR43 reduced the phosphorylation and nuclear translocation of nuclear factor-κB (NF-κB), which was relieved by short interfering RNA (siRNA) of β-arrestin 2. Subsequently, mRNA expression of proinflammatory cytokines, interleukin (IL)-6 and IL-1β, was downregulated by activation of GPR43 and knockdown of β-arrestin 2 recovered the expression of the cytokines. Taken together, these results suggest that GPR43 may be a plausible target for a variety of inflammatory diseases.
Details
- Language :
- English
- ISSN :
- 1347-5215
- Volume :
- 36
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Biological & pharmaceutical bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 23985900
- Full Text :
- https://doi.org/10.1248/bpb.b13-00312