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[Immunogenetic aspects of early rheumatoid arthritis].

Authors :
Guseva IA
Demidova NV
Soroka NE
Novikov AA
Luchikhina EL
Aleksandrova EN
Lukina GV
Fedorenko EV
Aronova ES
Samarkina EIu
Boldyreva MN
Trofimov DIu
Karateev DE
Nasonov EL
Source :
Vestnik Rossiiskoi akademii meditsinskikh nauk [Vestn Ross Akad Med Nauk] 2013 (4), pp. 36-43.
Publication Year :
2013

Abstract

The study is aimed to investigate the distribution of alleles of HLA-DRB1 gene in patients with early rheumatoid arthritis and healthy individuals in Russian population, and evaluate their significance as molecular genetic markers of rheumatoid arthritis predisposition and protection. The association between alleles of HLA-DRB1 genes, antibodies to cyclic citrullinated peptides and IgM rheumatoid factor was also studied. Low and high resolution HLA-DRB1 genotyping were compared. In the cohort of patients with early rheumatoid arthritis, the alleles of HLA-DRB1 gene were found to be markers of rheumatoid arthritis protection/risk, especially in the homozygous state. They determined production of antibodies to cyclic citrullinated peptides but were not associated with rheumatoid factor IgM levels. These findings support different autoimmune mechanisms of rheumatoid arthritis pathogenesis.

Details

Language :
Russian
ISSN :
0869-6047
Issue :
4
Database :
MEDLINE
Journal :
Vestnik Rossiiskoi akademii meditsinskikh nauk
Publication Type :
Academic Journal
Accession number :
24003720
Full Text :
https://doi.org/10.15690/vramn.v68i4.609