Cytotoxic constituents from the stems of Clausena lansium (Lour.) Skeels.

Authors :: Jiang HY
Wang CF
Fan L
Yang K
Feng JB
Geng ZF
Xu J
Deng ZW
Du SS
Yin HB
Source :: Molecules (Basel, Switzerland) [Molecules] 2013 Sep 03; Vol. 18 (9), pp. 10768-75. Date of Electronic Publication: 2013 Sep 03.
Publication Year :: 2013
Abstract: Six compounds were isolated from the stems of Clausena lansium (Lour.) Skeels by repeated sillica gel column chromatography. Their chemical structures were elucidated on the basic of physicochemical and spectroscopic data. Among them, 8-geranyloxypsolaren (3) and 2-methoxy-1-(3-methyl-buten-1-yl)-9H-carbazole-3-carbaldehyde (6) were isolated for the first time from this plant. These compounds were screened for cytotoxicity in human cervical cancer (Hela), leukemia (K562), lung cancer (A549), non-small lung carcinoma (H1299) and liver cancer (SMMC-7721). Within the series of cytotoxic tests, compounds 4-6 displayed potent cytotoxic activity against H1299 and SMMC-7721, with the IC₅₀ values of 6.19 to 26.84 μg/mL.