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Prognostic value of LA volumes assessed by transthoracic 3D echocardiography: comparison with 2D echocardiography.

Authors :
Wu VC
Takeuchi M
Kuwaki H
Iwataki M
Nagata Y
Otani K
Haruki N
Yoshitani H
Tamura M
Abe H
Negishi K
Lin FC
Otsuji Y
Source :
JACC. Cardiovascular imaging [JACC Cardiovasc Imaging] 2013 Oct; Vol. 6 (10), pp. 1025-1035. Date of Electronic Publication: 2013 Sep 04.
Publication Year :
2013

Abstract

Objectives: The hypothesis of this study was that minimal left atrial volume index (LAVImin) by 3-dimensional echocardiography (3DE) is the best predictor of future cardiovascular events.<br />Background: Although maximal left atrial volume index (LAVImax) by 2-dimensional echocardiography (2DE) is a robust index for predicting prognosis, the prognostic value of LAVImin and the superiority of measurements by 3DE over 2DE have not been determined in a large group of patients.<br />Methods: In protocol 1, we assessed age and sex dependency of LAVIs using 2DE and 3DE in 124 normal subjects and determined their cutoff values (mean + 2 SD). In protocol 2, 2-dimensional (2D) and 3-dimensional (3D) LAVImax/LAVImin were measured in 556 patients with high prevalence of cardiovascular disease. After excluding patients with atrial fibrillation, mitral valve disease, and age <18 years, 439 subjects were followed to record major adverse cardiovascular events (MACE). Patients were divided into 2 groups by the cutoff criteria of LAVI in each method.<br />Results: In protocol 1, there was no significant age and sex dependency for each 2D and 3D LAVI. In protocol 2, during a mean of 2.5 years of follow-up, MACE developed in 88 patients, including 32 cardiac deaths. Kaplan-Meier survival analyses showed that all 4 LAVI cutoff criteria had significant predictive power of MACE. After variables were adjusted for clinical variables and left ventricular ejection fraction, all 4 methods were still independently and significantly associated with MACE, but 3D-derived LAVImin had the highest risk ratio. 3D LAVImin also had an incremental prognostic value over 3D LAVImax.<br />Conclusions: LAVIs by both 2DE and 3DE are powerful predictors of future cardiac events. 3D LAVImin tended to have a stronger and additive prognostic value than 3D LAVImax.<br /> (Copyright © 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
1876-7591
Volume :
6
Issue :
10
Database :
MEDLINE
Journal :
JACC. Cardiovascular imaging
Publication Type :
Academic Journal
Accession number :
24011776
Full Text :
https://doi.org/10.1016/j.jcmg.2013.08.002