Back to Search
Start Over
Citrate inhibition of cisplatin reaction with DNA studied using fluorescently labeled oligonucleotides: implication for selectivity towards guanine.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2013 Oct 21; Vol. 49 (82), pp. 9482-4. - Publication Year :
- 2013
-
Abstract
- The reaction between cisplatin and DNA is conveniently studied using fluorescently labeled oligonucleotides and gel electrophoresis; as an example of application, the inhibition of this reaction by citrate is demonstrated, which might increase selectivity of cisplatin towards guanine over adenine.
- Subjects :
- Cisplatin antagonists & inhibitors
Cisplatin chemistry
Electrophoresis, Polyacrylamide Gel
Hydrogen-Ion Concentration
Molecular Structure
Substrate Specificity
Cisplatin pharmacology
Citric Acid pharmacology
DNA drug effects
Fluoresceins chemistry
Guanine chemistry
Oligonucleotides chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 49
- Issue :
- 82
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 24013823
- Full Text :
- https://doi.org/10.1039/c3cc45458d