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TNF receptor-associated factor 5 gene confers genetic predisposition to acute anterior uveitis and pediatric uveitis.
- Source :
-
Arthritis research & therapy [Arthritis Res Ther] 2013; Vol. 15 (5), pp. R113. - Publication Year :
- 2013
-
Abstract
- Introduction: TNF Receptor-Associated Factor 5 (TRAF5) has been shown to be associated with autoimmune disease. The current study sought to investigate the potential association of TRAF5 with acute anterior uveitis (AAU) and pediatric uveitis in Han Chinese.<br />Methods: Three TRAF5 SNPs were analyzed in 450 AAU patients with or without ankylosing spondylitis (AS), 458 pediatric uveitis patients, and 1,601 healthy controls by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) or TaqMan SNP Genotyping Assay. Numerous variables were evaluated, including age, sex distribution, and clinical and laboratory observations.<br />Results: Two SNPs (rs6540679, rs12569232) of TRAF5 were associated with pediatric uveitis, and rs12569232 also showed a relation with the presence of microvascular leakage. No significant associations were found when patients were subdivided according to their rheumatoid factor (RF) or anti-nuclear antibody (ANA) status or whether they had juvenile idiopathic arthritis (JIA). Rs12569232 predisposed to AAU and its subgroups (with ankylosing spondylitis (AS) or HLA-B27 positive). No association was found between rs10863888 and either pediatric uveitis or AAU.<br />Conclusion: This study revealed that TRAF5 is involved in the development of AAU and pediatric uveitis. Further stratified analysis according to the clinical and laboratory observations suggested that rs12569232/TRAF5 may play a role in the development of retinal vasculitis.
- Subjects :
- Acute Disease
Adult
Alleles
Child
Gene Frequency
Genotype
Humans
Linkage Disequilibrium
Middle Aged
Odds Ratio
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide
Spondylitis, Ankylosing complications
Uveitis, Anterior complications
Genetic Predisposition to Disease
TNF Receptor-Associated Factor 5 genetics
Uveitis genetics
Uveitis, Anterior genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1478-6362
- Volume :
- 15
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Arthritis research & therapy
- Publication Type :
- Academic Journal
- Accession number :
- 24020968
- Full Text :
- https://doi.org/10.1186/ar4293