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[Expression of EZH2 in breast cancer and its clinicopathological significance].
- Source :
-
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences [Zhejiang Da Xue Xue Bao Yi Xue Ban] 2013 Jul; Vol. 42 (4), pp. 443-9. - Publication Year :
- 2013
-
Abstract
- Objective: To investigate the expression of EZH2 in breast cancer and its clinicopathological significance.<br />Methods: Eighty cases of invasive breast cancer with complete clinlcpathological data and follow-up information were enrolled in the study. The expressions of ER, PR, HER-2, CK5/6, CK14, EGFR and EZH2 proteins were detected by immunohistochemistry (IHC). The relationship of EZH2 expression with molecular subtypes and prognosis of breast cancer was analyzed.<br />Results: In 80 cases of breast cancer, there were 49 cases of Luminal subtype, 8 cases of HER-2(+) subtype, 20 cases of Basal-like subtype and 3 cases of Normal breast-like subtype. The molecular subtypes of breast cancer were associated with menopausal status of patients. Luminal subtype had the highest overall survival rate, while the Basal-like carcinomas were associated with the lowest survival (P< 0.05). The overall EZH2-positive expression rate was 45.00% and the expression was correlated with axillary lymph node metastasis, histological grading and clinical staging of breast cancer (P < 0.05). The EZH2-positive expression rates in Luminal subtype, HER-2(+) subtype and Basal-like subtype of breast cancers were 34.6%,50.0% and 70.0%, respectively (P <0.05).<br />Conclusion: Positive expression of EZH2 may indicate a poor prognosis of breast cancer patients and it might be used as a novel therapeutic target for breast cancer of Basal-like subtype.
- Subjects :
- Adult
Aged
Aged, 80 and over
Enhancer of Zeste Homolog 2 Protein
Female
Humans
Immunohistochemistry
Lymphatic Metastasis
Middle Aged
Neoplasm Grading
Neoplasm Staging
Prognosis
Receptor, ErbB-2 metabolism
Breast Neoplasms metabolism
Breast Neoplasms pathology
Polycomb Repressive Complex 2 metabolism
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1008-9292
- Volume :
- 42
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences
- Publication Type :
- Academic Journal
- Accession number :
- 24022934
- Full Text :
- https://doi.org/10.3785/j.issn.1008-9292.2013.04.012