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Incidence and clinical course of Crohn's disease during the first year - results from the IBD Cohort of the Uppsala Region (ICURE) of Sweden 2005-2009.
- Source :
-
Journal of Crohn's & colitis [J Crohns Colitis] 2014 Mar; Vol. 8 (3), pp. 215-22. Date of Electronic Publication: 2013 Sep 12. - Publication Year :
- 2014
-
Abstract
- Background and Aims: As a part of the Swedish ICURE study where the epidemiological results of ulcerative colitis and microscopic colitis recently have been published, we hereby present the corresponding figures for Crohn's disease.<br />Methods: All patients diagnosed with Crohn's disease in Uppsala County (305,381 inhabitants) were prospectively registered during 2005-2006 and the same for all new patients with Crohn's disease in Uppsala Region (642,117 inhabitants) during 2007-2009.<br />Results: 264 patients with Crohn's disease were included. The mean annual incidence was 9.9/100,000/year (95% CI: 7.1-12.6). Incidence among children <17 years was 10.0/100,000/year (95% CI: 3.8-16.3). 51% of the patients had ileal involvement (L1: n=73, 28%. L2: n=129, 49%. L3: n=62, 23%, L4: n=47, 18%) and 23% had a stricturing or penetrating disease (B1: n=204, 77%. B2: n=34, 13%. B3: n=26, 10%. p: n=27, 10%). Intestinal resection rate during the first year was 12.5%. Patients with complicated disease had longer symptom duration before diagnosis compared to patients with non-complicated disease (median months 12.0, IQR: 3.0-24.0 vs 4.0, IQR: 2.0-12.0, p=0.0032). Patients 40 years or older had an increased risk for surgery (HR: 2.03, 95% CI: 1.01-4.08, p=0.0457).<br />Conclusions: The incidence of Crohn's disease in a region of Sweden is one of the highest reported in Europe. Long symptom duration precedes stricturing or penetrating behaviour. Old age is an independent risk factor for surgery.<br /> (© 2013.)
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Child
Child, Preschool
Colitis pathology
Colitis surgery
Constriction, Pathologic etiology
Constriction, Pathologic surgery
Crohn Disease pathology
Crohn Disease therapy
Female
Humans
Ileitis pathology
Ileitis surgery
Incidence
Male
Middle Aged
Phenotype
Risk Factors
Sweden epidemiology
Young Adult
Colitis epidemiology
Crohn Disease epidemiology
Ileitis epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1876-4479
- Volume :
- 8
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of Crohn's & colitis
- Publication Type :
- Academic Journal
- Accession number :
- 24035547
- Full Text :
- https://doi.org/10.1016/j.crohns.2013.08.009