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Age-dependent effect of high-fructose and high-fat diets on lipid metabolism and lipid accumulation in liver and kidney of rats.
- Source :
-
Lipids in health and disease [Lipids Health Dis] 2013 Sep 18; Vol. 12, pp. 136. Date of Electronic Publication: 2013 Sep 18. - Publication Year :
- 2013
-
Abstract
- Background: The metabolic syndrome (MS) is characterized by variable coexistence of metabolic and pathophysiological alterations which are important risk factors for developing of type II diabetes and/or cardiovascular diseases. Increased of MS patients in worldwide has stimulated the development of experimental models. However, it is still challenging to find an dietetic model that most closely approximates human MS and, in addition, is not yet fully established the effect of different diets of MS in lipid metabolism in rats of different ages. The aim of this study was to evaluate the effect of different diets of MS in lipid metabolism and ectopic fat deposition and define the most appropriate diet for inducing the characteristic disturbances of the human MS in rats of different ages.<br />Methods: Young (4 weeks old) and adult rats (12 weeks old) were given a high-fat (FAT) or high-fructose diet (FRU) for 13 weeks and biochemical, physiological, histological and biometric parameters were evaluated.<br />Results: In young rats, the FAT diet induced increased mean blood pressure (MAP) and heart rate (HR), body weight after 6 to 10 weeks, and in the 13th week, increased the liver, mesenteric, retroperitoneal and epididymal fat weights, fasting glucose, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and reduced HDL cholesterol; and also induced non-alcoholic fatty liver disease (NAFLD) and renal inflammatory infiltrates. In adult rats, the FRU diet induced transient elevations of MAP and HR in the 6th week, and, at 13 weeks, increased fasting glucose, triglycerides, total cholesterol, AST and ALT; increased liver, kidneys and retroperitoneal fat weights; and induced macrovesicular and microvesicular NAFLD, the presence of fat cells in the kidney, glomerular sclerosis, and liver and kidney inflammation. Additionally, the FAT and FRU diets induced, respectively, increases in liver glycogen in adults and young rats.<br />Conclusions: Our data show that FRU diet in adult rats causes biggest change on metabolism of serum lipids and lipid accumulation in liver and kidney, while the FAT diet in young rats induces elevation of MAP and HR and higher increased visceral lipid stores, constituting the best nutritional interventions to induce MS in rats.
- Subjects :
- Adipose Tissue drug effects
Age Factors
Animals
Blood Pressure drug effects
Body Weight drug effects
Dietary Fats adverse effects
Disease Models, Animal
Fatty Liver etiology
Fatty Liver pathology
Heart Rate drug effects
Humans
Kidney drug effects
Kidney pathology
Lipid Metabolism drug effects
Lipoproteins blood
Liver drug effects
Liver pathology
Male
Metabolic Syndrome etiology
Metabolic Syndrome pathology
Non-alcoholic Fatty Liver Disease
Rats
Rats, Inbred F344
Triglycerides blood
Diet, High-Fat
Fatty Liver metabolism
Fructose administration & dosage
Kidney metabolism
Liver metabolism
Metabolic Syndrome metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1476-511X
- Volume :
- 12
- Database :
- MEDLINE
- Journal :
- Lipids in health and disease
- Publication Type :
- Academic Journal
- Accession number :
- 24044579
- Full Text :
- https://doi.org/10.1186/1476-511X-12-136