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Quality of life in the follow-up of uveal melanoma patients after CyberKnife treatment.
- Source :
-
Melanoma research [Melanoma Res] 2013 Dec; Vol. 23 (6), pp. 481-8. - Publication Year :
- 2013
-
Abstract
- To assess quality of life in uveal melanoma patients within the first and second year after CyberKnife radiosurgery. Overall, 91 uveal melanoma patients were evaluated for quality of life through the Short-form (SF-12) Health Survey at baseline and at every follow-up visit over 2 years after CyberKnife radiosurgery. Statistical analysis was carried out using SF Health Outcomes Scoring Software and included subgroup analysis of patients developing secondary glaucoma and of patients maintaining a best corrected visual acuity (BCVA) of the treated eye of 0.5 log(MAR) or better. Analysis of variance, Greenhouse-Geisser correction, Student's t-test, and Fisher's exact test were used to determine statistical significance. Physical Functioning (PF) and Role Physical (RP) showed a significant decrease after CyberKnife radiosurgery, whereas Mental Health (MH) improved (P=0.007, P<0.0001 and P=0.023). MH and Social Functioning (SF) increased significantly (P=0.0003 and 0.026) in the no glaucoma group, MH being higher compared with glaucoma patients (P=0.02). PF and RP were significantly higher in patients with higher BCVA at the second follow-up (P=0.02). RP decreased in patients with BCVA<0.5 log(MAR) (P=0.013). Vitality (VT) increased significantly in patients whose BCVA could be preserved (P=0.031). Neither tumor localization nor size influenced the development of secondary glaucoma or change in BCVA. Although PF and RP decreased over time, MH improved continuously. Prevention of secondary glaucoma has a significant influence on both SF and MH, whereas preservation of BCVA affects VT. Emotional stability throughout follow-up contributes positively toward overall quality of life. CyberKnife radiosurgery may contribute to attenuation of emotional distress in uveal melanoma patients.
- Subjects :
- Adult
Aged
Aged, 80 and over
Female
Follow-Up Studies
Glaucoma complications
Humans
Male
Middle Aged
Outcome Assessment, Health Care
Quality of Life
Sex Factors
Stress, Psychological
Surveys and Questionnaires
Time Factors
Treatment Outcome
Vision, Ocular
Melanoma psychology
Melanoma surgery
Radiosurgery
Uveal Neoplasms psychology
Uveal Neoplasms surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1473-5636
- Volume :
- 23
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Melanoma research
- Publication Type :
- Academic Journal
- Accession number :
- 24048223
- Full Text :
- https://doi.org/10.1097/CMR.0000000000000023