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The role of technetium-99m methoxyisobutyl isonitrile scintigraphy in predicting the therapeutic effect of chemotherapy against nasopharyngeal carcinoma.
- Source :
-
Cancer [Cancer] 2011 Jun 01; Vol. 117 (11), pp. 2435-41. Date of Electronic Publication: 2010 Dec 14. - Publication Year :
- 2011
-
Abstract
- Background: The authors prospectively evaluated the correlation between technetium-99m methoxyisobutyl isonitrile ((99m) Tc-MIBI) accumulation in tumors and response to induction chemotherapy in patients with nasopharyngeal carcinoma (NPC).<br />Methods: Eighty-six patients with locally advanced NPC underwent single-photon emission computed tomography 15 minutes after an intravenous injection of 740 megabecquerels (20 mCi) (99m) Tc-MIBI before chemotherapy. The tumor uptake ratio (TUR) was calculated. Two weeks after the second cycle of combined chemotherapy with 5-fluorouracil (5-FU) and cisplatin (DDP), the tumor response rate was evaluated. The correlation between (99m) Tc-MIBI accumulation in tumors and response to chemotherapy with 5-FU/DDP was examined.<br />Results: Positive accumulation of (99m) Tc-MIBI in tumors was observed in 76 patients (88.4%). The tumor response was a complete response (CR) in 8 patients, a partial response (PR) in 68 patients, stable disease (SD) in 9 patients, and progressive disease (PD) in 1 patient. The response rate (CR and PR) to 5-FU/DDP chemotherapy in patients who had positive (99m) Tc-MIBI accumulation (tumor uptake ratio [TUR] >1.1) was higher than that in patients who had negative (99m) Tc-MIBI accumulation (TUR ≤ 1.1; 98.7% vs 10%; P < .001).<br />Conclusions: Patients with negative (99m) Tc-MIBI accumulation were resistant to 5-FU/DDP chemotherapy. (99m) Tc-MIBI imaging in patients with NPC was capable of predicting tumor response to chemotherapy with 5-FU/DDP and can help in the selection of patients for induction chemotherapy.<br /> (Copyright © 2010 American Cancer Society.)
- Subjects :
- Adult
Aged
Carcinoma
Drug Resistance, Neoplasm
Female
Humans
Male
Middle Aged
Nasopharyngeal Carcinoma
Neoadjuvant Therapy
Neoplasm Staging
Prognosis
Treatment Outcome
Young Adult
Antineoplastic Agents therapeutic use
Nasopharyngeal Neoplasms diagnosis
Nasopharyngeal Neoplasms drug therapy
Technetium Tc 99m Sestamibi
Tomography, Emission-Computed, Single-Photon
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0142
- Volume :
- 117
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 24048791
- Full Text :
- https://doi.org/10.1002/cncr.25802