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DNA microarray expression analysis of mouse kidney following cadmium exposure for 12 months.
- Source :
-
The Journal of toxicological sciences [J Toxicol Sci] 2013; Vol. 38 (5), pp. 799-802. - Publication Year :
- 2013
-
Abstract
- Cadmium (Cd) is a toxic heavy metal and chronic exposure causes kidney injury. This study used DNA microarray analysis to examine gene expression in the kidney of mice chronically exposed to Cd. Female C57BL/6J mice were fed a 300 ppm Cd-containing diet or a control diet for 12 months. In comparison with control mice, the expression levels of 32 genes, including Hmox1 and Mt2, were elevated more than 2.0-fold, whereas 113 genes, including transport- and ubiquitination-related genes, were reduced less than 0.5-fold.
- Subjects :
- Animals
Cadmium Compounds administration & dosage
Female
Gene Expression Profiling
Mice
Mice, Inbred C57BL
Oligonucleotide Array Sequence Analysis
Time Factors
Cadmium Compounds toxicity
Gene Expression drug effects
Heme Oxygenase-1 metabolism
Kidney metabolism
Kidney Diseases chemically induced
Kidney Diseases genetics
Membrane Proteins metabolism
Metallothionein metabolism
Up-Regulation drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1880-3989
- Volume :
- 38
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The Journal of toxicological sciences
- Publication Type :
- Academic Journal
- Accession number :
- 24067728
- Full Text :
- https://doi.org/10.2131/jts.38.799