Back to Search
Start Over
PAQR-2 regulates fatty acid desaturation during cold adaptation in C. elegans.
- Source :
-
PLoS genetics [PLoS Genet] 2013; Vol. 9 (9), pp. e1003801. Date of Electronic Publication: 2013 Sep 12. - Publication Year :
- 2013
-
Abstract
- C. elegans PAQR-2 is homologous to the insulin-sensitizing adiponectin receptors in mammals, and essential for adaptation to growth at 15°C, a low but usually acceptable temperature for this organism. By screening for novel paqr-2 suppressors, we identified mutations in genes involved in phosphatidylcholine synthesis (cept-1, pcyt-1 and sams-1) and fatty acid metabolism (ech-7, hacd-1, mdt-15, nhr-49 and sbp-1). We then show genetic evidence that paqr-2, phosphatidylcholines, sbp-1 and Δ9-desaturases form a cold adaptation pathway that regulates the increase in unsaturated fatty acids necessary to retain membrane fluidity at low temperatures. This model is supported by the observations that the paqr-2 suppressors normalize the levels of saturated fatty acids, and that low concentrations of detergents that increase membrane fluidity can rescue the paqr-2 mutant.<br />Competing Interests: The authors have declared that no competing interests exist.
- Subjects :
- Animals
Caenorhabditis elegans genetics
Caenorhabditis elegans physiology
Cold Temperature
Fatty Acids chemistry
Insulin metabolism
Mutation
Phosphatidylcholines metabolism
Receptors, Adiponectin metabolism
Temperature
Adaptation, Physiological genetics
Caenorhabditis elegans Proteins genetics
Fatty Acids metabolism
Lipid Metabolism genetics
Membrane Proteins genetics
Receptors, Adiponectin genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1553-7404
- Volume :
- 9
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- PLoS genetics
- Publication Type :
- Academic Journal
- Accession number :
- 24068966
- Full Text :
- https://doi.org/10.1371/journal.pgen.1003801