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Evaluation of the efficacies of Amphotericin B, Posaconazole, Voriconazole, and Anidulafungin in a murine disseminated infection by the emerging opportunistic Fungus Sarocladium (Acremonium) kiliense.
- Source :
-
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2013 Dec; Vol. 57 (12), pp. 6265-9. Date of Electronic Publication: 2013 Oct 07. - Publication Year :
- 2013
-
Abstract
- We evaluated and compared the efficacies of different antifungal drugs against Sarocladium kiliense (formerly Acremonium kiliense), a clinically relevant opportunistic fungus, in a murine model of systemic infection. Three clinical strains of this fungus were tested, and the therapy administered was as follows: posaconazole at 20 mg/kg of body weight (twice daily), voriconazole at 40 mg/kg, anidulafungin at 10 mg/kg, or amphotericin B at 0.8 mg/kg. The efficacy was evaluated by prolonged animal survival, tissue burden reduction, and (1→3)-β-d-glucan serum levels. In general, the four antifungal drugs showed high MICs and poor in vitro activity. The efficacy of the different treatments was only modest, since survival rates were never higher than 40% and no drug was able to reduce fungal load in all the organs for the three strains tested. Posaconazole, in spite of its high MICs (≥16 μg/ml), showed the highest efficacy. The (1→3)-β-d-glucan serum levels were equally reduced by all drugs evaluated.
- Subjects :
- Amphotericin B pharmacology
Amphotericin B therapeutic use
Anidulafungin
Animals
Echinocandins pharmacology
Echinocandins therapeutic use
Male
Mice
Pyrimidines pharmacology
Pyrimidines therapeutic use
Triazoles pharmacology
Triazoles therapeutic use
Voriconazole
Acremonium drug effects
Acremonium pathogenicity
Antifungal Agents pharmacology
Antifungal Agents therapeutic use
Mycoses drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1098-6596
- Volume :
- 57
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Antimicrobial agents and chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 24100490
- Full Text :
- https://doi.org/10.1128/AAC.01484-13