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[Interest of the study of a not identified peak on a hemoglobin chromatogram: delta variant or inter-sample contaminations?].

Authors :
Desmons A
Jaisson S
Gillery P
Guillard E
Source :
Annales de biologie clinique [Ann Biol Clin (Paris)] 2013 Sep-Oct; Vol. 71 (5), pp. 577-80.
Publication Year :
2013

Abstract

D-10(®) (Bio-Rad) analyzer using cationic exchange high performance chromatography (HPLC) allows the detection of the main hemoglobin variants. This observation shows the presence of a peak on chromatogram with a low intensity and no quantifiable which can lead to different diagnosis. Inter-sample contaminations can be confused with the presence of an hemoglobin variant. This case highlights the importance of the knowledge of technicals limits for validation and clinical use of results.

Details

Language :
French
ISSN :
1950-6112
Volume :
71
Issue :
5
Database :
MEDLINE
Journal :
Annales de biologie clinique
Publication Type :
Academic Journal
Accession number :
24113442
Full Text :
https://doi.org/10.1684/abc.2013.0867