Identification of mureidomycin analogues and functional analysis of an N-acetyltransferase in napsamycin biosynthesis.

Authors :: Tang X
Gross M
Xie Y
Kulik A
Gust B
Source :: Chembiochem : a European journal of chemical biology [Chembiochem] 2013 Nov 25; Vol. 14 (17), pp. 2248-55. Date of Electronic Publication: 2013 Oct 02.
Publication Year :: 2013
Abstract: Antibiotic abundance: Several new uridyl peptide antibiotics were identified from a heterologous producer strain containing the mureidomycin/napsamycin biosynthetic gene cluster by using HRMS and LC-ESI-MS/MS. Analysis of the new compounds and the corresponding gene cluster revealed NpsB, an N-acetyltransferase, to be responsible for acetylation of the uridyl peptide antibiotic.<br /> (Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Subjects :: Acetylation
Molecular Conformation
Multigene Family
Nucleosides biosynthesis
Nucleosides chemistry
Nucleosides metabolism
Streptomyces enzymology
Streptomyces genetics
Streptomyces metabolism
Acetyltransferases metabolism

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