Back to Search
Start Over
Cannabinoids alter endothelial function in the Zucker rat model of type 2 diabetes.
- Source :
-
European journal of pharmacology [Eur J Pharmacol] 2013 Nov 15; Vol. 720 (1-3), pp. 376-82. Date of Electronic Publication: 2013 Oct 08. - Publication Year :
- 2013
-
Abstract
- Circulating levels of anandamide are increased in diabetes, and cannabidiol ameliorates a number of pathologies associated with diabetes. The aim of the present study was to examine how exposure to anandamide or cannabidiol might affect endothelial dysfunction associated with Zucker Diabetic Fatty rats. Age-matched Zucker Diabetic Fatty and Zucker lean rats were killed by cervical dislocation and their arteries mounted on a myograph at 37 °C. Arteries were incubated for 2h with anandamide, cannabidiol or vehicle, contracted, and cumulative concentration-response curves to acetylcholine were constructed. Anandamide (10 µM, 2h) significantly improved the vasorelaxant responses to acetylcholine in aortae and femoral arteries from Zucker Diabetic Fatty rats but not Zucker lean rats. By contrast, anandamide (1 µM, 2h) significantly blunted acetylcholine-induced vasorelaxation in third-order mesenteric arteries (G3) from Zucker Diabetic Fatty rats. Cannabidiol incubation (10 µM, 2h) improved acetylcholine responses in the arteries of Zucker Diabetic Fatty rats (aorta and femoral) and Zucker lean (aorta, femoral and G3 mesenteric), and this effect was greater in the Zucker Diabetic Fatty rat. These studies suggest that increased circulating endocannabinoids may alter vascular function both positively and negatively in type 2 diabetes, and that part of the beneficial effect of cannabidiol in diabetes may be due to improved endothelium-dependent vasorelaxation.<br /> (© 2013 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Aorta, Thoracic drug effects
Aorta, Thoracic physiology
Disease Models, Animal
Endothelium, Vascular physiopathology
Femoral Artery drug effects
Femoral Artery physiology
Male
Mesenteric Arteries drug effects
Mesenteric Arteries physiology
Rats
Rats, Zucker
Vasodilation drug effects
Arachidonic Acids pharmacology
Cannabidiol pharmacology
Diabetes Mellitus, Type 2 physiopathology
Endocannabinoids pharmacology
Endothelium, Vascular drug effects
Polyunsaturated Alkamides pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0712
- Volume :
- 720
- Issue :
- 1-3
- Database :
- MEDLINE
- Journal :
- European journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 24120371
- Full Text :
- https://doi.org/10.1016/j.ejphar.2013.10.002