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Levels of HVA, 5-HIAA, and MHPG in the CSF of vascular parkinsonism compared to Parkinson's disease and controls.
- Source :
-
Journal of neurology [J Neurol] 2013 Dec; Vol. 260 (12), pp. 3129-33. - Publication Year :
- 2013
-
Abstract
- The neurochemical abnormalities underlying vascular parkinsonism (VP) have not been well characterised. A better understanding may help to optimize pharmacological interventions. Since VP patients generally have a poorer response to l-Dopa than Parkinson's disease (PD) patients, we investigated whether levels of relevant CSF neurotransmitter metabolites may be differentially altered in VP and PD and assessed the potential of neurotransmitter metabolites as biomarkers. We compared CSF levels of homovanillic acid (HVA), 5-hydroxyindolacetic acid, and 3-methoxy-4-hydroxyphenylethyleneglycol, in 16 VP patients, 57 PD patients and 60 non-neurological controls. We found that levels of HVA were reduced in PD compared with both VP and controls but did not differ significantly between VP and controls indicating that dopamine deficiency was less pronounced in VP.
- Subjects :
- Aged
Cerebrovascular Disorders cerebrospinal fluid
Cerebrovascular Disorders complications
Female
Humans
Male
Middle Aged
Parkinson Disease, Secondary etiology
Homovanillic Acid cerebrospinal fluid
Hydroxyindoleacetic Acid cerebrospinal fluid
Methoxyhydroxyphenylglycol cerebrospinal fluid
Parkinson Disease cerebrospinal fluid
Parkinson Disease, Secondary cerebrospinal fluid
Subjects
Details
- Language :
- English
- ISSN :
- 1432-1459
- Volume :
- 260
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Journal of neurology
- Publication Type :
- Academic Journal
- Accession number :
- 24122060
- Full Text :
- https://doi.org/10.1007/s00415-013-7126-5