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Nude mice are nonpermissive towards the anti-dextran response of congenic cells.

Authors :
Weiler IJ
Sprenger R
Weiler E
Source :
European journal of immunology [Eur J Immunol] 1985 Nov; Vol. 15 (11), pp. 1102-6.
Publication Year :
1985

Abstract

Nude mice bearing allotype Ighb on a BALB/c genetic background (= CB nu/nu) are nonresponders to alpha (1----3)dextran (Dex), in contrast to BALB/c or BALB/c nu/nu. Although CB nu/nu mice accept transplants of congenic BALB/c, or BALB nu/nu lymphocytes, as shown by the expression of donor allotype Igha, they are not permissive for a primary anti-Dex response by the grafted cells. BALB/c or BALB nu/nu cells, however, give a strong anti-Dex response when grafted onto irradiated CB nu/nu or CB 23 (Ighb) euthymic mice. A thymus-independent, radiation-sensitive suppressor cell population is postulated, which specifically hinders the anti-Dex response, and which is exhibited by strains bearing that portion of chromosome 12 which codes for CH allotype Ighb, not containing the germ-line anti-Dex V/D genes. The suppressive action of Ighb lymphocytes could be demonstrated directly in staggered co-transfer experiments.

Details

Language :
English
ISSN :
0014-2980
Volume :
15
Issue :
11
Database :
MEDLINE
Journal :
European journal of immunology
Publication Type :
Academic Journal
Accession number :
2415366
Full Text :
https://doi.org/10.1002/eji.1830151107