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Effect of atorvastatin on baroreflex sensitivity in subjects with type 2 diabetes and dyslipidaemia.

Authors :
Grigoropoulou P
Eleftheriadou I
Zoupas C
Makrilakis K
Papassotiriou I
Margeli A
Perrea D
Katsilambros N
Tentolouris N
Source :
Diabetes & vascular disease research [Diab Vasc Dis Res] 2014 Jan; Vol. 11 (1), pp. 26-33. Date of Electronic Publication: 2013 Oct 23.
Publication Year :
2014

Abstract

In this prospective study, we examined the effect of atorvastatin treatment on baroreflex sensitivity (BRS) in subjects with type 2 diabetes. A total of 79 patients with type 2 diabetes with dyslipidaemia were recruited. A total of 46 subjects were enrolled to atorvastatin 10 mg daily and low-fat diet and 33 patients to low-fat diet only. BRS was assessed non-invasively using the sequence method at baseline, 3, 6 and 12 months. Treatment with atorvastatin increased BRS after 12 months (from 6.46 ± 2.79 ms/mmHg to 8.05 ± 4.28 ms/mmHg, p = 0.03), while no effect was seen with low-fat diet. Further sub-analysis according to obesity status showed that BRS increased significantly only in the non-obese group (p = 0.036). A low dose of atorvastatin increased BRS in non-obese subjects with type 2 diabetes and dyslipidaemia after 1-year treatment. This finding emphasizes the beneficial effect of atorvastatin on cardiovascular system, beyond the lipid-lowering effects.

Details

Language :
English
ISSN :
1752-8984
Volume :
11
Issue :
1
Database :
MEDLINE
Journal :
Diabetes & vascular disease research
Publication Type :
Academic Journal
Accession number :
24154932
Full Text :
https://doi.org/10.1177/1479164113508293