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Prevalence of dengue virus infection in US travelers who have lived in or traveled to dengue-endemic countries.
- Source :
-
Journal of travel medicine [J Travel Med] 2013 Nov-Dec; Vol. 20 (6), pp. 352-60. Date of Electronic Publication: 2013 Aug 16. - Publication Year :
- 2013
-
Abstract
- Background: Dengue virus (DENV) infections may occur in travelers.<br />Objectives: To determine prevalence of anti-DENV IgG antibody in travelers who lived in or visited dengue-endemic countries and to describe risk factors and characteristics associated with infection and subsequent anti-DENV IgG antibody presence.<br />Methods: Participants were enrolled from travel clinics of the Boston Area Travel Medicine Network from August 2008 through June 2009. Demographic information, trip duration, travel history, and a blood sample were collected. Serum samples were tested for anti-DENV IgG antibody by indirect IgG enzyme-linked immunosorbent assay (ELISA), and antibody-mediated virus neutralization by plaque reduction neutralization test (PRNT) for anti-DENV IgG antibody-positive and selected negative samples. Participants were stratified into group 1: born in dengue-endemic countries; group 2: born in nonendemic countries but lived continuously for ≥1 year in a dengue-endemic country; group 3: born in nonendemic countries and traveled to a dengue-endemic country for ≥2 weeks but <1 year.<br />Results: Six hundred travelers were enrolled. Anti-DENV IgG antibody was identified in 113 (19%) when tested by ELISA (51% in group 1, 40% in group 2, and 6.9% in group 3) and in 71 (12%) by PRNT (42% primary monotypic and 58% heterotypic reactive responses). Sensitivity and specificity of the ELISA based on PRNT results were 85% to 100% and 79% to 94%, assuming up to 15% misclassification of ELISA negative results. Presence of anti-DENV IgG antibody by ELISA was associated with years lived in dengue-endemic countries and birthplace in the Caribbean for group 1, receipt of Japanese encephalitis vaccine in group 3, and self-reported history of dengue in all three groups.<br />Conclusions: Nineteen percent of participants who were born, lived in, or traveled to dengue-endemic countries had anti-DENV IgG antibody by ELISA; 12% had antibodies by PRNT, 85% of whom had no history of dengue. Presence of DENV antibodies was associated with years lived in dengue-endemic countries and self-reported history of dengue.<br /> (© 2013 International Society of Travel Medicine.)
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Boston epidemiology
Caribbean Region ethnology
Child
Dengue virology
Enzyme-Linked Immunosorbent Assay
Female
Follow-Up Studies
Humans
Male
Middle Aged
Prevalence
Retrospective Studies
Young Adult
Antibodies, Viral analysis
Dengue ethnology
Dengue Virus immunology
Endemic Diseases
Immunoglobulin G immunology
Travel
Subjects
Details
- Language :
- English
- ISSN :
- 1708-8305
- Volume :
- 20
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of travel medicine
- Publication Type :
- Academic Journal
- Accession number :
- 24165381
- Full Text :
- https://doi.org/10.1111/jtm.12057