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Molecular characterization of scant lung tumor cells using iron-oxide nanoparticles and micro-nuclear magnetic resonance.

Authors :
Ghazani AA
Pectasides M
Sharma A
Castro CM
Mino-Kenudson M
Lee H
Shepard JA
Weissleder R
Source :
Nanomedicine : nanotechnology, biology, and medicine [Nanomedicine] 2014 Apr; Vol. 10 (3), pp. 661-8. Date of Electronic Publication: 2013 Nov 04.
Publication Year :
2014

Abstract

Advances in nanotechnology and microfluidics are enabling the analysis of small amounts of human cells. We tested whether recently developed micro-nuclear magnetic resonance (μNMR) technology could be leveraged for diagnosing pulmonary malignancy using fine needle aspirate (FNA) of primary lesions and/or peripheral blood samples. We enrolled a cohort of 35 patients referred for CT biopsy of primary pulmonary nodules, liver or adrenal masses and concurrently obtained FNA and peripheral blood samples. FNA sampling yielded sufficient material for μNMR analysis in 91% of cases and had a sensitivity and specificity of 91.6% and 100% respectively. Interestingly, among blood samples with positive circulating tumor cells (CTC), μNMR analysis of each patient's peripheral blood led to similar diagnosis (malignant vs benign) and differential diagnosis (lung malignancy subtype) in 100% and 90% (18/20) of samples, respectively. μNMR appears to be a valuable, non-invasive adjunct in the diagnosis of lung cancer.<br />From the Clinical Editor: The authors of this study established that recently developed micro-nuclear magnetic resonance (μNMR) technology can be leveraged for diagnosing pulmonary malignancy using fine needle aspirate (FNA) of primary lesions and/or peripheral blood samples derived from 35 patients, suggesting practical clinical applicability of this technique.<br /> (Copyright © 2014 Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
1549-9642
Volume :
10
Issue :
3
Database :
MEDLINE
Journal :
Nanomedicine : nanotechnology, biology, and medicine
Publication Type :
Academic Journal
Accession number :
24200523
Full Text :
https://doi.org/10.1016/j.nano.2013.10.008