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Green synthesis and biological evaluation of new di-α-aminophosphonate derivatives as cytotoxic agents.
- Source :
-
Archiv der Pharmazie [Arch Pharm (Weinheim)] 2013 Dec; Vol. 346 (12), pp. 851-9. Date of Electronic Publication: 2013 Nov 11. - Publication Year :
- 2013
-
Abstract
- A series of novel di-α-aminophosphonate derivatives were synthesized by a one-pot method in the presence of PEG-H2 O under ultrasonic irradiation and were characterized by IR, (1) H NMR, (13) C NMR, mass spectrometry, and elemental analysis. The newly synthesized compounds were evaluated for their cytotoxic activities against the human lung cancer cell line H1299 and the human breast cancer cell line MCF7 in vitro by the MTT method. All compounds showed moderate cytotoxic activity on both cell lines, and compounds 4b and 4c showed marked activity.<br /> (© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Cell Survival drug effects
Dose-Response Relationship, Drug
Humans
MCF-7 Cells
Magnetic Resonance Spectroscopy
Mass Spectrometry
Molecular Structure
Polyethylene Glycols chemistry
Spectrophotometry, Infrared
Structure-Activity Relationship
Time Factors
Ultrasonics methods
Water chemistry
Antineoplastic Agents chemical synthesis
Antineoplastic Agents pharmacology
Green Chemistry Technology
Organophosphonates chemical synthesis
Organophosphonates pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1521-4184
- Volume :
- 346
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Archiv der Pharmazie
- Publication Type :
- Academic Journal
- Accession number :
- 24214666
- Full Text :
- https://doi.org/10.1002/ardp.201300249